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Podder I, Mondal H, Kroumpouzos G. Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients. Int J Womens Dermatol. 2021;7(4):403-410doi: 10.1016/j.ijwd.2021.02.010.
Podder, I., Mondal, H., & Kroumpouzos, G. (2021). Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients. International journal of women's dermatology, 7(4), 403-410. https://doi.org/10.1016/j.ijwd.2021.02.010
Podder, Indrashis, et al. "Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients." International journal of women's dermatology vol. 7,4 (2021): 403-410. doi: https://doi.org/10.1016/j.ijwd.2021.02.010
Podder I, Mondal H, Kroumpouzos G. Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients. Int J Womens Dermatol. 2021 Mar 03;7(4):403-410. doi: 10.1016/j.ijwd.2021.02.010. eCollection 2021 Sep. PMID: 34632036; PMCID: PMC8484989.
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Int J Womens Dermatol. 2021 Mar 03;7(4):403-410. doi: 10.1016/j.ijwd.2021.02.010. eCollection 2021 Sep.

Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients.

International journal of women's dermatology

Indrashis Podder, Himel Mondal, George Kroumpouzos

Affiliations

  1. Department of Dermatology, Venereology, and Leprosy, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
  2. Department of Physiology, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India.
  3. Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.
  4. Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil.
  5. GK Dermatology, PC, South Weymouth, Massachusetts.

PMID: 34632036 PMCID: PMC8484989 DOI: 10.1016/j.ijwd.2021.02.010

Abstract

Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep deficit, which can lead to physical and mental disturbances (e.g., daytime somnolence and fatigue) and negative emotional states that profoundly affect quality of life. However, this aspect of NP is often overlooked by dermatologists. It is essential to assess sleep quality in such patients and adopt appropriate measures to arrest the problem at an early stage. We conducted an evidence-based literature review to highlight the pathogenetic mechanisms of NP, identify dermatologic etiologies, and explore methods that have been used to assess the quality of sleep. Furthermore, we performed a systematic review of studies on sleep disturbance relevant to NP in patients with dermatologic conditions. Finally, we discuss the evidence on treatment options for NP and indicate therapies that may target both NP and sleep disturbance.

© 2021 The Author(s).

Keywords: Nocturnal pruritus; quality of life; skin diseases; sleep disturbance; therapy

Conflict of interest statement

None.

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