Display options
Cite
Maegele M. Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI). Transfus Med Rev. 2021;35(4):87-90doi: 10.1016/j.tmrv.2021.08.003.
Maegele, M. (2021). Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI). Transfusion medicine reviews, 35(4), 87-90. https://doi.org/10.1016/j.tmrv.2021.08.003
Maegele, Marc. "Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI)." Transfusion medicine reviews vol. 35,4 (2021): 87-90. doi: https://doi.org/10.1016/j.tmrv.2021.08.003
Maegele M. Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI). Transfus Med Rev. 2021 Oct;35(4):87-90. doi: 10.1016/j.tmrv.2021.08.003. Epub 2021 Sep 04. PMID: 34598876.
Copy Download .nbib Format: NLM
Share it on

Transfus Med Rev. 2021 Oct;35(4):87-90. doi: 10.1016/j.tmrv.2021.08.003. Epub 2021 Sep 04.

Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI).

Transfusion medicine reviews

Marc Maegele

Affiliations

  1. Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center (CMMC), University Witten/Herdecke, Cologne, Germany; Institute for Research in Operative Medicine (IFOM), University Witten/Herdecke, Cologne, Germany; Treatment Center for Traumatic Injuries, 3rd Affiliated Hospital Southern Medical University (SMU), Guangdong Province, People's Republic, China. Electronic address: [email protected].

PMID: 34598876 DOI: 10.1016/j.tmrv.2021.08.003

Abstract

Traumatic brain injury (TBI) remains a significant medical and socioeconomic challenge. The initial injury may be complicated by haemostatic derangements leading to exacerbation of lesions and haemorrhagic progression. The results from the CRASH-3 trial have promoted the implementation of the antifibrinolytic tranexamic acid (TXA) into prehospital Emergency Medical Services (EMS) protocols. Very recently, the efficacy and safety of early out-of-hospital TXA compared to placebo was assessed in patients with moderate or severe TBI in a prospective, multicenter phase II trial, e.g. "The Prehospital TXA for TBI"-trial. Simultaneously, the results from a retrospective analysis of prospectively collected observational data into the Dutch pre-hospital TBI database were published which had assessed whether prehospital administration of TXA may be associated with mortality and functional outcomes in patients with severe TBI. Both studies are reviewed against their limitations and windows of opportunity are highlighted.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Prehospital; Tranexamic acid; Traumatic brain injury; Treatment

Publication Types