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Oddo LE, Acuff SF, Arenson MB, et al. Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms. Alcohol Alcohol. 2021;doi: 10.1093/alcalc/agab070.
Oddo, L. E., Acuff, S. F., Arenson, M. B., Oshri, A., Chronis-Tuscano, A., MacKillop, J., & Murphy, J. G. (2021). Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms. Alcohol and alcoholism (Oxford, Oxfordshire), . https://doi.org/10.1093/alcalc/agab070
Oddo, Lauren E, et al. "Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms." Alcohol and alcoholism (Oxford, Oxfordshire) vol. (2021). doi: https://doi.org/10.1093/alcalc/agab070
Oddo LE, Acuff SF, Arenson MB, Oshri A, Chronis-Tuscano A, MacKillop J, Murphy JG. Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms. Alcohol Alcohol. 2021 Oct 09; doi: 10.1093/alcalc/agab070. Epub 2021 Oct 09. PMID: 34632479.
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Alcohol Alcohol. 2021 Oct 09; doi: 10.1093/alcalc/agab070. Epub 2021 Oct 09.

Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms.

Alcohol and alcoholism (Oxford, Oxfordshire)

Lauren E Oddo, Samuel F Acuff, Melanie B Arenson, Assaf Oshri, Andrea Chronis-Tuscano, James MacKillop, James G Murphy

Affiliations

  1. Department of Psychology, University of Maryland, 4094 Campus Dr, College Park, MD 20742, USA.
  2. Department of Psychology, University of Memphis, 400 Innovation Dr, Memphis, TN 38111, USA.
  3. Department of Human Development and Family Science, University of Georgia, 305 Sanford Dr. Athens, GA 30602, USA.
  4. Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main Street West | Hamilton, Ontario L8S4L8 Canada.

PMID: 34632479 DOI: 10.1093/alcalc/agab070

Abstract

AIMS: Contemporary theories of attention-deficit/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) emphasize core dysfunctions in reward-related processes and behaviors as pathognomonic characteristics. However, to date, it is unclear which domains of reward functioning are unique to ADHD versus AUD symptom dimensions, and which represent underlying shared correlates.

METHODS: The current study employed secondary data analyses from a large community sample of emerging adults (N = 602; 57.3% female) and novel transdiagnostic modeling (i.e. bi-factor confirmatory factor analyses and structural equation modeling) of ADHD, AUD and shared symptom dimensions to identify unique and common reward-related dimensions: environmental suppressors, reward probability, hedonic capacity, proportionate substance-related reinforcement and delay discounting.

RESULTS: The presence of environmental suppressors was the only reward-related construct that correlated with the underlying ADHD-AUD shared dimension. The AUD symptom dimension was uniquely associated with proportionate substance-related reinforcement, whereas the ADHD symptom dimension was uniquely associated with limited reward probability. No significant associations were found for delay discounting or hedonic capacity.

CONCLUSIONS: These novel findings highlight specific aspects of reward-related functioning in ADHD, AUD and shared symptom dimensions. In so doing, this work meaningfully advances theoretical conceptualizations of these two commonly co-occurring presentations and suggests future directions for research on transdiagnostic correlates. Future longitudinal studies should include clinical samples with diagnoses of AUD and ADHD to further identify underlying correlates over time.

© The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved.

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