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Dundas JA, Hassanabad AF, Zarzycki AN, et al. Ischemic heart disease: Cellular and molecular immune contributions of the pericardium. Int J Biochem Cell Biol. 2021;140:106076doi: 10.1016/j.biocel.2021.106076.
Dundas, J. A., Hassanabad, A. F., Zarzycki, A. N., Fedak, P. W., & Deniset, J. F. (2021). Ischemic heart disease: Cellular and molecular immune contributions of the pericardium. The international journal of biochemistry & cell biology, 140106076. https://doi.org/10.1016/j.biocel.2021.106076
Dundas, Jameson A, et al. "Ischemic heart disease: Cellular and molecular immune contributions of the pericardium." The international journal of biochemistry & cell biology vol. 140 (2021): 106076. doi: https://doi.org/10.1016/j.biocel.2021.106076
Dundas JA, Hassanabad AF, Zarzycki AN, Fedak PW, Deniset JF. Ischemic heart disease: Cellular and molecular immune contributions of the pericardium. Int J Biochem Cell Biol. 2021 Nov;140:106076. doi: 10.1016/j.biocel.2021.106076. Epub 2021 Sep 17. PMID: 34543760.
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Int J Biochem Cell Biol. 2021 Nov;140:106076. doi: 10.1016/j.biocel.2021.106076. Epub 2021 Sep 17.

Ischemic heart disease: Cellular and molecular immune contributions of the pericardium.

The international journal of biochemistry & cell biology

Jameson A Dundas, Ali Fatehi Hassanabad, Anna N Zarzycki, Paul Wm Fedak, Justin F Deniset

Affiliations

  1. Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, Calgary, Alberta, Canada.
  2. Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pharmacology and Physiology, University of Calgary, Calgary, Alberta, Canada. Electronic address: [email protected].

PMID: 34543760 DOI: 10.1016/j.biocel.2021.106076

Abstract

Ischemic heart disease promotes complex inflammatory and remodeling pathways which contribute to the development of chronic heart failure. Although blood-derived and local cardiac mediators have traditionally been linked with these processes, the pericardial space has more recently been noted as alternative contributor to the injury response in the heart. The pericardial space contains fluid rich in physiologically active mediators, and immunologically active adipose tissue, which are altered during myocardial infarction. Key immune cells in the pericardial fluid and adipose tissue have been identified which act as mediators for cell recruitment and function after myocardial infarction have been identified in experimental models. Here, we provide an overview of the current understanding of the inflammatory mechanisms of the pericardial space and their role in post-myocardial infarction remodeling and the potential for the use of the pericardial space as a delivery vehicle for treatments to modulate heart healing.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Immune Cells; Inflammation; Ischemic Heart Disease; Pericardium

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