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Riva N, Attard LM, Vella K, et al. Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis. Thromb Res. 2021;207:102-112doi: 10.1016/j.thromres.2021.09.016.
Riva, N., Attard, L. M., Vella, K., Squizzato, A., Gatt, A., & Calleja-Agius, J. (2021). Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis. Thrombosis research, 207102-112. https://doi.org/10.1016/j.thromres.2021.09.016
Riva, Nicoletta, et al. "Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis." Thrombosis research vol. 207 (2021): 102-112. doi: https://doi.org/10.1016/j.thromres.2021.09.016
Riva N, Attard LM, Vella K, Squizzato A, Gatt A, Calleja-Agius J. Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis. Thromb Res. 2021 Sep 27;207:102-112. doi: 10.1016/j.thromres.2021.09.016. Epub 2021 Sep 27. PMID: 34600286.
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Thromb Res. 2021 Sep 27;207:102-112. doi: 10.1016/j.thromres.2021.09.016. Epub 2021 Sep 27.

Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis.

Thrombosis research

Nicoletta Riva, Laura Maria Attard, Kevin Vella, Alessandro Squizzato, Alex Gatt, Jean Calleja-Agius

Affiliations

  1. Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: [email protected].
  2. Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: [email protected].
  3. Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: [email protected].
  4. Department of Medicine and Surgery, University of Insubria, Como, Italy. Electronic address: [email protected].
  5. Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: [email protected].
  6. Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: [email protected].

PMID: 34600286 DOI: 10.1016/j.thromres.2021.09.016

Abstract

BACKGROUND: D-dimer is included in the diagnostic algorithm for deep vein thrombosis and pulmonary embolism. However, its role in the diagnosis of splanchnic vein thrombosis (SVT) is still controversial. The aim of this study was to evaluate the diagnostic accuracy of D-dimer for SVT.

METHODS: We performed a systematic review of the literature with meta-analysis (PROSPERO protocol registration number: CRD42020184300). The electronic databases MEDLINE, EMBASE, and CENTRAL were searched from inception to March 2021 week 4. Studies which evaluated D-dimer accuracy for SVT in any category of patients were selected. The index test was any D-dimer assay; the reference standard was any radiological imaging. The QUADAS-2 checklist was used for the risk of bias assessment. A bivariate random-effects regression model was used to calculate summary estimates of sensitivity and specificity.

RESULTS: 12 studies (with a total of 1298 patients) evaluating the accuracy of D-dimer in patients at high risk of SVT (surgical patients, patients with liver cirrhosis or hepatocellular carcinoma) were included. None of the included studies was at low risk of bias. The weighted mean prevalence of SVT was 33.4% (95% CI, 22.5-45.2%, I

CONCLUSIONS: D-dimer seems to have high sensitivity in the diagnosis of patients at high-risk for SVT. However, there is a strong need for more robust evidence on this topic.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Fibrin fibrinogen degradation products; Liver cirrhosis; Splanchnic circulation; Systematic review; Venous thrombosis

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