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Ruby KN, Harm SK, Dunbar NM. Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components. Transfus Med Rev. 2021;35(4):118-122doi: 10.1016/j.tmrv.2021.06.006.
Ruby, K. N., Harm, S. K., & Dunbar, N. M. (2021). Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components. Transfusion medicine reviews, 35(4), 118-122. https://doi.org/10.1016/j.tmrv.2021.06.006
Ruby, Kristen N, et al. "Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components." Transfusion medicine reviews vol. 35,4 (2021): 118-122. doi: https://doi.org/10.1016/j.tmrv.2021.06.006
Ruby KN, Harm SK, Dunbar NM. Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components. Transfus Med Rev. 2021 Oct;35(4):118-122. doi: 10.1016/j.tmrv.2021.06.006. Epub 2021 Aug 25. PMID: 34544619.
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Transfus Med Rev. 2021 Oct;35(4):118-122. doi: 10.1016/j.tmrv.2021.06.006. Epub 2021 Aug 25.

Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components.

Transfusion medicine reviews

Kristen N Ruby, Sarah K Harm, Nancy M Dunbar

Affiliations

  1. Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  2. Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA; University of Vermont Larner College of Medicine, Burlington, VT, USA.
  3. Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: [email protected].

PMID: 34544619 DOI: 10.1016/j.tmrv.2021.06.006

Abstract

The last several decades have seen significant changes in the approach to resuscitation of bleeding patients. These include the adoption of ABO-incompatible plasma transfusion in the form of group A plasma and/or low titer group O whole blood for trauma patients of unknown ABO group. Studies to date have examined the impact of these practices on patient outcomes and clinical markers of hemolysis in recipients of ABO-incompatible plasma compared to those for whom the plasma is ABO-compatible. Risk for increased mortality and/or overt hemolysis appear to be low among recipients of ABO-incompatible plasma; however, nearly all of studies are retrospective and most have focused only on adult trauma patients so results may not be generalizable to other bleeding patients. Work continues to evaluate the role of various titer thresholds in decreasing hemolytic risk and opportunities remain to improve our understanding of anti-A and anti-B antibody interactions with complement/endothelium and identify strategies to minimize risk.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Hemolysis; Incompatible; Massive Transfusion; Plasma

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