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Manikkath J, Subramony JA. Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems. Adv Drug Deliv Rev. 2021;179:113997doi: 10.1016/j.addr.2021.113997.
Manikkath, J., & Subramony, J. A. (2021). Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems. Advanced drug delivery reviews, 179113997. https://doi.org/10.1016/j.addr.2021.113997
Manikkath, Jyothsna, and Subramony, J Anand. "Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems." Advanced drug delivery reviews vol. 179 (2021): 113997. doi: https://doi.org/10.1016/j.addr.2021.113997
Manikkath J, Subramony JA. Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems. Adv Drug Deliv Rev. 2021 Dec;179:113997. doi: 10.1016/j.addr.2021.113997. Epub 2021 Oct 08. PMID: 34634396.
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Adv Drug Deliv Rev. 2021 Dec;179:113997. doi: 10.1016/j.addr.2021.113997. Epub 2021 Oct 08.

Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems.

Advanced drug delivery reviews

Jyothsna Manikkath, J Anand Subramony

Affiliations

  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India. Electronic address: [email protected].
  2. Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA. Electronic address: [email protected].

PMID: 34634396 DOI: 10.1016/j.addr.2021.113997

Abstract

The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: COVID-19; Closed-loop drug delivery systems; Microneedles; On-demand drug delivery; Self-powered wearables; Skin-interfaced wearables; Transdermal drug delivery; Wearables; Wearables for drug delivery

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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