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de La Flor JC, Gomez-Berrocal A, Marschall A, et al. Impacto de la corrección temprana de la hiponatremia en el pronóstico de la infección del síndrome respiratorio agudo grave del coronavirus 2 (SARS-CoV-2). The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection. Med Clin (Barc). 2021;doi: 10.1016/j.medcli.2021.07.006.
de La Flor, J. C., Gomez-Berrocal, A., Marschall, A., Valga, F., Linares, T., Albarracin, C., Ruiz, E., Gallegos, G., Gómez, A., de Los Santos, A., & Rodeles, M. (2021). Impacto de la corrección temprana de la hiponatremia en el pronóstico de la infección del síndrome respiratorio agudo grave del coronavirus 2 (SARS-CoV-2). The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection. Medicina clinica, . https://doi.org/10.1016/j.medcli.2021.07.006
de La Flor, José C, et al. "Impacto de la corrección temprana de la hiponatremia en el pronóstico de la infección del síndrome respiratorio agudo grave del coronavirus 2 (SARS-CoV-2)." The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection. Medicina clinica vol. (2021). doi: https://doi.org/10.1016/j.medcli.2021.07.006
de La Flor JC, Gomez-Berrocal A, Marschall A, Valga F, Linares T, Albarracin C, Ruiz E, Gallegos G, Gómez A, de Los Santos A, Rodeles M. Impacto de la corrección temprana de la hiponatremia en el pronóstico de la infección del síndrome respiratorio agudo grave del coronavirus 2 (SARS-CoV-2). The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection. Med Clin (Barc). 2021 Jul 29; doi: 10.1016/j.medcli.2021.07.006. Epub 2021 Jul 29. Spanish. PMID: 34635318; PMCID: PMC8318697.
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Med Clin (Barc). 2021 Jul 29; doi: 10.1016/j.medcli.2021.07.006. Epub 2021 Jul 29.

The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection.

Medicina clinica

[Article in Spanish]
José C de La Flor, Ana Gomez-Berrocal, Alexander Marschall, Francisco Valga, Tania Linares, Cristina Albarracin, Elisa Ruiz, Gioconda Gallegos, Alberto Gómez, Andrea de Los Santos, Miguel Rodeles

Affiliations

  1. Servicio de Nefrología, Hospital Central de la Defensa Gómez Ulla, Madrid, España. Electronic address: [email protected].
  2. Servicio de Medicina Interna, Hospital Central de la Defensa Gómez Ulla, Madrid, España.
  3. Servicio de Cardiología, Hospital Central de la Defensa Gómez Ulla, Madrid, España.
  4. Servicio de Nefrología, Hospital Negrín, Gran Canaria, España.
  5. Servicio de Nefrología, Hospital Central de la Defensa Gómez Ulla, Madrid, España.
  6. Facultad de Medicina, Universidad Alcalá de Henares, Madrid, España.

PMID: 34635318 PMCID: PMC8318697 DOI: 10.1016/j.medcli.2021.07.006

Abstract

INTRODUCTION: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium<135mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20-37% according to the series, but there are no data on the prognosis after correction of hyponatremia. Therefore, our objectives were: to analyze the incidence and severity of hyponatremia at hospital admission, and to determine the association of this hyponatremia with the prognosis of COVID-19.

MATERIAL AND METHOD: Observational and retrospective cohort study. Patients who were admitted with a diagnosis of COVID-19 infection and hyponatremia, in the period March-May 2020, were included. We recorded epidemiological, demographic, clinical, biochemical, and radiological variables of SARS-CoV-2 infection and hyponatremia at the time of diagnosis and during hospitalization. The clinical follow-up ranged from admission to death or discharge.

RESULTS: 91 patients (21.8%) of the 414 admitted for SARS-CoV-2 infection presented hyponatremia (81.32% mild hyponatremia, 9.89% moderate and 8.79% severe). The absence of correction of hyponatremia 72-96h after hospital admission was associated with higher mortality in patients with COVID-19 (Odds Ratio .165; 95% confidence interval: .018-.686; P=.011). 19 patients (20.9%) died. An increase in mortality was observed in patients with severe hyponatremia compared with moderate and mild hyponatremia during hospital admission (37.5% versus 11.1% versus 8.1%, P=.041).

CONCLUSIONS: We conclude that persistence of hyponatremia at 72-96h of hospital admission was associated with higher mortality in patients with SARS-CoV-2.

Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

Keywords: Coronavirus disease 2019; Enfermedad del coronavirus 2019; Hiponatremia y mortalidad; Hyponatremia and mortality; Severe acute respiratory syndrome coronavirus 2; Síndrome respiratorio agudo grave del coronavirus 2

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