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Krishna M, Krishnaveni GV, Sargur V, et al. Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India. Int Psychogeriatr. 2021;1-14doi: 10.1017/S1041610221001186.
Krishna, M., Krishnaveni, G. V., Sargur, V., Kumaran, K., Kumar, M., Nagaraj, K., Coakley, P., Karat, S. C., Chandak, G. R., Varghese, M., Prince, M., Osmond, C., & Fall, C. H. D. (2021). Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India. International psychogeriatrics, 1-14. https://doi.org/10.1017/S1041610221001186
Krishna, Murali, et al. "Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India." International psychogeriatrics vol. (2021): 1-14. doi: https://doi.org/10.1017/S1041610221001186
Krishna M, Krishnaveni GV, Sargur V, Kumaran K, Kumar M, Nagaraj K, Coakley P, Karat SC, Chandak GR, Varghese M, Prince M, Osmond C, Fall CHD. Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India. Int Psychogeriatr. 2021 Oct 20;1-14. doi: 10.1017/S1041610221001186. Epub 2021 Oct 20. PMID: 34666849.
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Int Psychogeriatr. 2021 Oct 20;1-14. doi: 10.1017/S1041610221001186. Epub 2021 Oct 20.

Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India.

International psychogeriatrics

Murali Krishna, Ghattu V Krishnaveni, Veena Sargur, Kalyanaraman Kumaran, Mohan Kumar, Kiran Nagaraj, Patsy Coakley, Samuel Chirstaprasad Karat, Giriraj R Chandak, Mathew Varghese, Martin Prince, Clive Osmond, Caroline H D Fall

Affiliations

  1. CSI Holdsworth Memorial Hospital, Mandimohalla, Mysore, India.
  2. Foundation for Research and Advocacy in Mental Health Mysore, Mysore, India.
  3. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  4. Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  5. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
  6. National Institute of Mental Health and Neurosciences, Bangalore, India.
  7. Institute of Psychiatry, Kings College London, London, UK.

PMID: 34666849 DOI: 10.1017/S1041610221001186

Abstract

OBJECTIVE: To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming.

DESIGN: Longitudinal follow-up of a birth cohort.

SETTING: CSI Holdsworth Memorial Hospital (HMH), Mysore South India.

PARTICIPANTS: 721 men and women (55-80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life.

MEASUREMENTS: Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders.

RESULTS: Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants' own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI -0.01, 0.18] p = 0.07).

CONCLUSIONS: The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.

Keywords: Developmental Origins of Health and Disease (DOHaD); Low- and Middle-Income Countries (LMIC); birth weight; cardiometabolic disorders; cognition

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