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Diagnostics (Basel). 2021 Sep 03;11(9). doi: 10.3390/diagnostics11091606.

Patients with Systemic Sclerosis with and without Overlap Syndrome Show Similar Microvascular Abnormalities.

Diagnostics (Basel, Switzerland)

Gabriella Nagy, László Czirják, Gábor Kumánovics

Affiliations

  1. Department of Rheumatology and Immunology, Medical School, University of Pécs, Akác Street 1, 7362 Pécs, Hungary.

PMID: 34573948 PMCID: PMC8468290 DOI: 10.3390/diagnostics11091606

Abstract

INTRODUCTION: Nailfold video capillaroscopy (NVC) is a useful tool for measuring capillary density (CD) and capillary morphology parameters and is mainly used in systemic sclerosis (SSc).

OBJECTIVE: We aimed to assess the prevalence of an SSc pattern and CD in different connective tissue diseases (CTDs).

METHODS: NVC was performed on 268 patients with CTDs. Control groups consisted of 104 healthy volunteers (HVs) and 36 primary Raynaud's patients (PRPs).

RESULTS: Decreased CD was more prevalent in SSc, systemic lupus erythematosus (SLE), inflammatory myopathies (IIM), and overlap CTD patients compared with both controls. Average CD, the prevalence of decreased CD, and the prevalence of an SSc pattern did not differ significantly between SSc patients with (

CONCLUSION: The presence of another CTD in SSc did not influence CD or morphology. An SSc pattern may also be present in CTDs other than SSc. The MES is a useful instrument to distinguish between patients with CTDs and controls.

Keywords: SSc pattern; capillary density; connective tissue diseases; nailfold video capillaroscopy; systemic sclerosis

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