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Zhang X, Liu H, Meena N, et al. Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game. Chem Sci. 2021;12(37):12451-12462doi: 10.1039/d1sc03188k.
Zhang, X., Liu, H., Meena, N., Li, C., Zong, G., Raben, N., Puertollano, R., & Wang, L. X. (2021). Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game. Chemical science, 12(37), 12451-12462. https://doi.org/10.1039/d1sc03188k
Zhang, Xiao, et al. "Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game." Chemical science vol. 12,37 (2021): 12451-12462. doi: https://doi.org/10.1039/d1sc03188k
Zhang X, Liu H, Meena N, Li C, Zong G, Raben N, Puertollano R, Wang LX. Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game. Chem Sci. 2021 Aug 19;12(37):12451-12462. doi: 10.1039/d1sc03188k. eCollection 2021 Sep 29. PMID: 34603676; PMCID: PMC8480326.
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Chem Sci. 2021 Aug 19;12(37):12451-12462. doi: 10.1039/d1sc03188k. eCollection 2021 Sep 29.

Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game.

Chemical science

Xiao Zhang, Huiying Liu, Naresh Meena, Chao Li, Guanghui Zong, Nina Raben, Rosa Puertollano, Lai-Xi Wang

Affiliations

  1. Department of Chemistry and Biochemistry, University of Maryland 8051 Regents Drive College Park Maryland 20742 USA [email protected].
  2. Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH Bethesda Maryland 20892 USA.

PMID: 34603676 PMCID: PMC8480326 DOI: 10.1039/d1sc03188k

Abstract

Functionalization of therapeutic lysosomal enzymes with mannose-6-phosphate (M6P) glycan ligands represents a major strategy for enhancing the cation-independent M6P receptor (CI-MPR)-mediated cellular uptake, thus improving the overall therapeutic efficacy of the enzymes. However, the minimal high-affinity M6P-containing

This journal is © The Royal Society of Chemistry.

Conflict of interest statement

L. X. W is the founder and a major shareholder of GlycoT Therapeutics. Other authors declare no potential conflicts of interest.

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