Exp Gerontol. 2021 Nov;155:111582. doi: 10.1016/j.exger.2021.111582. Epub 2021 Oct 09.
Association between functional physical capacity and cognitive performance under destabilizing walking conditions in older adults.
Experimental gerontology
Pei-Chun Kao, Michaela A Pierro, Tong Wu, Daniela M Gonzalez, Rachel Seeley
Affiliations
Affiliations
- Department of Physical Therapy and Kinesiology, University of Massachusetts Lowell, Lowell, MA, United States; New England Robotics Validation and Experimentation (NERVE) Center, University of Massachusetts Lowell, Lowell, MA, United States. Electronic address: [email protected].
- Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, Lowell, MA, United States.
- Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, United States.
- Department of Biomedical Engineering, University of Massachusetts Lowell, Lowell, MA, United States.
- Department of Physical Therapy and Kinesiology, University of Massachusetts Lowell, Lowell, MA, United States.
PMID: 34637948
DOI: 10.1016/j.exger.2021.111582
Abstract
BACKGROUND: Cognitive decline increases the risk of falls in older adults. Understanding the association between cognitive function, functional physical capacity, and falls may help identify targets for fall screening and intervention. This study examined (1) cognitive and functional physical capacity in community-dwelling older adults with and without a history of falls or the presence of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism (Val/Met), and (2) the association between their cognitive and functional physical capacity, focusing on the cognitive performance during dual-task, challenging walking conditions.
METHODS: Twenty-nine healthy, community-dwelling older adults attended two testing sessions for (1) functional assessments of physical capacity and global cognitive status, and (2) performing four cognitive tasks (visual and auditory Stroop tasks, Clock task, and Paced Auditory Serial Addition Test) during standing and while walking on the treadmill with and without medio-lateral treadmill platform sways.
RESULTS: Participants with a fall history had reduced functional reach distance whereas individuals with Val/Met had reduced functional gait assessment (FGA) score compared to their controls. In addition, participants with a fall history or Val/Met showed reduced Clock task performance under dual-task conditions. Among all cognitive tasks, visual-Stroop performance, especially during the perturbed walking conditions, was significantly correlated with more physical capacity items. The performance of the other three cognitive tasks provided complementary information on those items not correlated with visual-Stroop performance.
CONCLUSIONS: Clock task performance can distinguish fallers from non-fallers as well as older adults with and without the BDNF gene polymorphism. Administering different types of cognitive tasks and under more challenging walking conditions can better reveal the association between cognitive and functional physical capacity in older adults. Fall screening and prevention intervention should integrate cognitive tasks into the functional physical capacity assessment and training regime, and progress to a more challenging condition such as introducing gait or balance perturbations during the assessment or training.
Copyright © 2021 Elsevier Inc. All rights reserved.
Keywords: BDNF gene polymorphism; Cognitive function; Dual-task; Falls; Older adults; Perturbation
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