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Kouchoukos NT, Haynes M, Hester S, et al. Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement. Aorta (Stamford). 2021;9(3):100-105doi: 10.1055/s-0041-1726279.
Kouchoukos, N. T., Haynes, M., Hester, S., & Castner, C. F. (2021). Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement. Aorta (Stamford, Conn.), 9(3), 100-105. https://doi.org/10.1055/s-0041-1726279
Kouchoukos, Nicholas T, et al. "Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement." Aorta (Stamford, Conn.) vol. 9,3 (2021): 100-105. doi: https://doi.org/10.1055/s-0041-1726279
Kouchoukos NT, Haynes M, Hester S, Castner CF. Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement. Aorta (Stamford). 2021 Jun;9(3):100-105. doi: 10.1055/s-0041-1726279. Epub 2021 Oct 12. PMID: 34638147; PMCID: PMC8598313.
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Aorta (Stamford). 2021 Jun;9(3):100-105. doi: 10.1055/s-0041-1726279. Epub 2021 Oct 12.

Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement.

Aorta (Stamford, Conn.)

Nicholas T Kouchoukos, Marc Haynes, Sarah Hester, Catherine F Castner

Affiliations

  1. Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, BJC Healthcare, St. Louis, Missouri.

PMID: 34638147 PMCID: PMC8598313 DOI: 10.1055/s-0041-1726279

Abstract

BACKGROUND:  Uncertainty remains regarding the optimal method of brain protection for procedures that require repair or replacement of the aortic arch. We examined the early outcomes of a technique for brain protection in patients undergoing partial aortic arch (hemiarch) replacement that involves deep hypothermic circulatory arrest (DHCA) and retrograde cerebral perfusion (RCP) of cold blood from the superior vena cava toward the end of the arrest interval.

METHODS:  During a recent 15-year interval, 520 patients underwent elective or urgent/emergent ascending aortic and hemiarch replacement as an isolated (47 patients) or combined (473 patients) procedure employing DHCA (mean nasopharyngeal temperature at circulatory arrest, 17.1°C and mean duration, 19.3 minutes) supplemented with RCP of cold blood from the superior vena cava toward the end of the arrest interval (mean, 6.7 minutes). The mean age of the patients was 59.5 years, and 65% were male.

RESULTS:  The in-hospital and 30-day mortality rates were 1.2% (six patients). Seven patients (1.4%) sustained a stroke and 19 patients (3.7%) had transient neurologic dysfunction that completely resolved by the time of hospital discharge. Four patients (0.77%) developed postoperative renal failure requiring dialysis. Twenty-one patients (4%) required ventilator support for >48 hours and five patients (0.96%) required a tracheostomy. The median hospital length of stay was 6 days.

CONCLUSION:  DHCA with a brief interval of RCP is a safe and effective technique for brain protection during hemiarch aortic replacement. RCP reduces the duration of brain ischemia and permits removal of particulate matter and air from the arterial circulation.

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Conflict of interest statement

The authors declare no conflict of interest related to this article.

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