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Monnamorn L, Seree-Aphinan C, Molika P, et al. The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection. Front Med (Lausanne). 2021;8:724371doi: 10.3389/fmed.2021.724371.
Monnamorn, L., Seree-Aphinan, C., Molika, P., Vichitkunakorn, P., Pattanapanyasat, K., Khwannimit, B., & Navakanitworakul, R. (2021). The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection. Frontiers in medicine, 8724371. https://doi.org/10.3389/fmed.2021.724371
Monnamorn, Latthawan, et al. "The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection." Frontiers in medicine vol. 8 (2021): 724371. doi: https://doi.org/10.3389/fmed.2021.724371
Monnamorn L, Seree-Aphinan C, Molika P, Vichitkunakorn P, Pattanapanyasat K, Khwannimit B, Navakanitworakul R. The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection. Front Med (Lausanne). 2021 Sep 16;8:724371. doi: 10.3389/fmed.2021.724371. eCollection 2021. PMID: 34604260; PMCID: PMC8481381.
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Front Med (Lausanne). 2021 Sep 16;8:724371. doi: 10.3389/fmed.2021.724371. eCollection 2021.

The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection.

Frontiers in medicine

Latthawan Monnamorn, Chutima Seree-Aphinan, Piyatida Molika, Polathep Vichitkunakorn, Kovit Pattanapanyasat, Bodin Khwannimit, Raphatphorn Navakanitworakul

Affiliations

  1. Faculty of Medicine, Department of Biomedical Sciences and Biomedical Engineering, Prince of Songkla University, Songkhla, Thailand.
  2. Faculty of Medicine, Department of Internal Medicine, Prince of Songkla University, Songkhla, Thailand.
  3. Faculty of Medicine, Department of Family and Preventive Medicine, Prince of Songkla University, Songkhla, Thailand.
  4. Faculty of Medicine Siriraj Hospital, Department of Research and Development, Mahidol University, Bangkok, Thailand.

PMID: 34604260 PMCID: PMC8481381 DOI: 10.3389/fmed.2021.724371

Abstract

Septic shock represents a subset of sepsis with severe physiological aberrations and a higher mortality rate than sepsis alone. Currently, the laboratory tools which can be used to identify the state of septic shock are limited. In pre-clinical studies, extracellular vesicles (EVs), especially large EVs (lEVs), have been demonstrated a role as functional inflammatory mediators of sepsis. However, its longitudinal trend during the disease course has not been explored. In this study, the quantities and subtypes of plasma-derived lEVs were longitudinally compared between patients with septic shock (

Copyright © 2021 Monnamorn, Seree-aphinan, Molika, Vichitkunakorn, Pattanapanyasat, Khwannimit and Navakanitworakul.

Keywords: extracellular vesicles; imaging flow cytometry; microparticles; microvesicles; sepsis; septic shock

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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