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Ventura E, Iannuzzi CA, Pentimalli F, et al. RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Cancers (Basel). 2021;13(19)doi: 10.3390/cancers13195025.
Ventura, E., Iannuzzi, C. A., Pentimalli, F., Giordano, A., & Morrione, A. (2021). RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Cancers, 13(19), . https://doi.org/10.3390/cancers13195025
Ventura, Elisa, et al. "RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways." Cancers vol. 13,19 (2021). doi: https://doi.org/10.3390/cancers13195025
Ventura E, Iannuzzi CA, Pentimalli F, Giordano A, Morrione A. RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Cancers (Basel). 2021 Oct 08;13(19). doi: 10.3390/cancers13195025. PMID: 34638509; PMCID: PMC8507926.
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Cancers (Basel). 2021 Oct 08;13(19). doi: 10.3390/cancers13195025.

RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways.

Cancers

Elisa Ventura, Carmelina Antonella Iannuzzi, Francesca Pentimalli, Antonio Giordano, Andrea Morrione

Affiliations

  1. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
  2. Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, I-80131 Napoli, Italy.
  3. Department of Medical Biotechnologies, University of Siena, I-53100 Siena, Italy.

PMID: 34638509 PMCID: PMC8507926 DOI: 10.3390/cancers13195025

Abstract

The members of the retinoblastoma (RB) protein family, RB1/p105, retinoblastoma-like (RBL)1/p107 and RBL2/p130 are critical modulators of the cell cycle and their dysregulation has been associated with tumor initiation and progression. The activity of RB proteins is regulated by numerous pathways including oncogenic signaling, but the molecular mechanisms of these functional interactions are not fully defined. We previously demonstrated that RBL2/p130 is a direct target of AKT and it is a key mediator of the apoptotic process induced by AKT inhibition. Here we demonstrated that RBL1/p107 levels are only minorly modulated by the AKT signaling pathway. In contrast, we discovered that RBL1/p107 levels are regulated by multiple pathways linked directly or indirectly to Ca

Keywords: AKT; CaMK; RBL1/p107

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