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Ngandu T, Lehtisalo J, Korkki S, et al. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement. 2021;doi: 10.1002/alz.12492.
Ngandu, T., Lehtisalo, J., Korkki, S., Solomon, A., Coley, N., Antikainen, R., Bäckman, L., Hänninen, T., Lindström, J., Laatikainen, T., Paajanen, T., Havulinna, S., Peltonen, M., Neely, A. S., Strandberg, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2021). The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12492
Ngandu, Tiia, et al. "The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12492
Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, Bäckman L, Hänninen T, Lindström J, Laatikainen T, Paajanen T, Havulinna S, Peltonen M, Neely AS, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement. 2021 Oct 20; doi: 10.1002/alz.12492. Epub 2021 Oct 20. PMID: 34668644.
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Alzheimers Dement. 2021 Oct 20; doi: 10.1002/alz.12492. Epub 2021 Oct 20.

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto

Affiliations

  1. Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  2. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.
  3. Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
  4. Department of Psychology, University of Cambridge, Cambridge, UK.
  5. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
  6. Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.
  7. Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France.
  8. Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.
  9. Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  10. Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
  11. Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
  12. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  13. Joint municipal authority for North Karelia social and health services (Siun sote), Joensuu, Finland.
  14. Finnish Institute of Occupational Health, Helsinki, Finland.
  15. Department of Public Health and Welfare, Functioning and Service Needs Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  16. Department of Social Psychological Sciences, Karlstad University, Karlstad, Sweden.
  17. Engineering Psychology, Luleå University of Technology, Luleå, Sweden.
  18. Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  19. Department of Public Health, University of Helsinki, Helsinki, Finland.
  20. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
  21. South Ostrobothnia Central Hospital, Seinäjoki, Finland.
  22. Theme Aging, Karolinska University Hospital, Solna, Sweden.

PMID: 34668644 DOI: 10.1002/alz.12492

Abstract

INTRODUCTION: Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).

METHODS: FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.

RESULTS: Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.

DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.

Alzheimer's & Dementia© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Keywords: cognition; lifestyle; multidomain; prevention

References

  1. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396:413-446. - PubMed
  2. Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14:653-666. - PubMed
  3. Coley N, Ngandu T, Lehtisalo J, et al. Adherence to multidomain interventions for dementia prevention: data from the FINGER and MAPT trials. Alzheimers Dement. 2019;15:729-741. - PubMed
  4. Beishuizen CRL, Coley N, Moll van Charante EP, van Gool WA, Richard E, Andrieu S. Determinants of dropout and nonadherence in a dementia prevention randomized controlled trial: the prevention of dementia by intensive vascular care trial. J Am Geriatr Soc. 2017;65:1505-1513. - PubMed
  5. Clare L, Nelis SM, Jones IR, et al. The Agewell trial: a pilot randomised controlled trial of a behaviour change intervention to promote healthy ageing and reduce risk of dementia in later life. BMC Psychiatry. 2015;15:25. - PubMed
  6. Lehtisalo J, Ngandu T, Valve P, et al. Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial. Br J Nutr. 2017;118:291-302. - PubMed
  7. de Souto Barreto P, Rolland Y, Cesari M, Dupuy C, Andrieu S, Vellas B. Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial. Age Ageing. 2018;47:281-288. - PubMed
  8. Lam LC, Chan WC, Leung T, Fung AW, Leung EM. Would older adults with mild cognitive impairment adhere to and benefit from a structured lifestyle activity intervention to enhance cognition?: a cluster randomized controlled trial. PLoS One. 2015;10:e0118173. - PubMed
  9. Lehtisalo J, Levalahti E, Lindstrom J, et al. Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Alzheimers Dement. 2018;15:410-417. - PubMed
  10. Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255-2263. - PubMed
  11. Kivipelto M, Solomon A, Ahtiluoto S, et al. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress. Alzheimers Dement. 2013;9:657-665. - PubMed
  12. Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006;5:735-741. - PubMed
  13. National Nutrition Council. Finnish nutrition recommendations - Diet and physical activity in balance. Edita Publishing Ltd; Helsinki. 2005. - PubMed
  14. Komulainen P, Kivipelto M, Lakka TA, et al. Exercise, fitness and cognition - A randomised controlled trial in older individuals: the DR's EXTRA study. Eur Geriatr Med. 2010;1:266-272. - PubMed
  15. Nelson ME, Rejeski WJ, Blair SN, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1094-1105. - PubMed
  16. Turunen M, Hokkanen L, Backman L, et al. Computer-based cognitive training for older adults: determinants of adherence. PLoS One. 2019;14:e0219541. - PubMed
  17. Dahlin E, Neely AS, Larsson A, Backman L, Nyberg L. Transfer of learning after updating training mediated by the striatum. Science. 2008;320:1510-1512. - PubMed
  18. Lakka TA, Venalainen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med. 1994;330:1549-1554. - PubMed
  19. Rosenberg A, Ngandu T, Rusanen M, et al. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial. Alzheimers Dement. 2018;14:263-270. - PubMed
  20. Harrison J, Minassian SL, Jenkins L, Black RS, Koller M, Grundman M. A neuropsychological test battery for use in Alzheimer disease clinical trials. Arch Neurol. 2007;64:1323-1329. - PubMed
  21. Risk reduction of cognitive decline and dementia: WHO guidelines. Geneva: World Health Organization; 2019. Licence: CC BY-NCSA 3.0 IGO. - PubMed
  22. Rebok GW, Langbaum JB, Jones RN, et al. Memory training in the ACTIVE study: how much is needed and who benefits?. J Aging Health. 2013;25:21S-42S. - PubMed
  23. Isaacson RS, Hristov H, Saif N, et al. Individualized clinical management of patients at risk for Alzheimer's dementia. Alzheimers Dement. 2019;15:1588-1602. - PubMed
  24. Andrieu S, Guyonnet S, Coley N, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017;16:377-389. - PubMed
  25. Moll van Charante EP, Richard E, Eurelings LS, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016;388:797-805. - PubMed
  26. Lindstrom J, Ilanne-Parikka P, Peltonen M, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 2006;368:1673-1679. - PubMed
  27. Harrington MG, Chiang J, Pogoda JM, et al. Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study. PLoS One. 2013;8:e79378. - PubMed
  28. Fiatarone Singh MA, Gates N, Saigal N, et al. The Study of Mental and Resistance Training (SMART) study-resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc. 2014;15:873-880. - PubMed
  29. Matz K, Teuschl Y, Firlinger B, et al. Multidomain lifestyle interventions for the prevention of cognitive decline after ischemic stroke: randomized trial. Stroke. 2015;46:2874-2880. - PubMed
  30. Ngandu T, Lehtisalo J, Levälahti E, et al. Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) - a randomized controlled lifestyle trial. Int J Env Res Public Health. 2014;11:9345-9360. - PubMed
  31. Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006;333:15. - PubMed
  32. Lourida I, Hannon E, Littlejohns TJ, et al. Association of lifestyle and genetic risk with incidence of dementia. JAMA. 2019;322:430-437. - PubMed
  33. Nyberg ST, Singh-Manoux A, Pentti J, et al. Association of healthy lifestyle with years lived without major chronic diseases. JAMA Intern Med. 2020;180:760-768. - PubMed
  34. Rutten-Jacobs LC, Larsson SC, Malik R, et al. Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants. BMJ. 2018;363:k4168. - PubMed
  35. Kivipelto M, Mangialasche F, Snyder HM, et al. World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020;16:1078-1094. - PubMed

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