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Vanhatalo S, Dall'Asta M, Cossu M, et al. Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults. J Nutr. 2021;doi: 10.1093/jn/nxab361.
Vanhatalo, S., Dall'Asta, M., Cossu, M., Chiavaroli, L., Francinelli, V., Pede, G. D., Dodi, R., Närväinen, J., Antonini, M., Goldoni, M., Holopainen-Mantila, U., Cas, A. D., Bonadonna, R., Brighenti, F., Poutanen, K., & Scazzina, F. (2021). Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults. The Journal of nutrition, . https://doi.org/10.1093/jn/nxab361
Vanhatalo, Saara, et al. "Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults." The Journal of nutrition vol. (2021). doi: https://doi.org/10.1093/jn/nxab361
Vanhatalo S, Dall'Asta M, Cossu M, Chiavaroli L, Francinelli V, Pede GD, Dodi R, Närväinen J, Antonini M, Goldoni M, Holopainen-Mantila U, Cas AD, Bonadonna R, Brighenti F, Poutanen K, Scazzina F. Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults. J Nutr. 2021 Oct 20; doi: 10.1093/jn/nxab361. Epub 2021 Oct 20. PMID: 34669959.
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J Nutr. 2021 Oct 20; doi: 10.1093/jn/nxab361. Epub 2021 Oct 20.

Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults.

The Journal of nutrition

Saara Vanhatalo, Margherita Dall'Asta, Marta Cossu, Laura Chiavaroli, Veronica Francinelli, Giuseppe Di Pede, Rossella Dodi, Johanna Närväinen, Monica Antonini, Matteo Goldoni, Ulla Holopainen-Mantila, Alessandra Dei Cas, Riccardo Bonadonna, Furio Brighenti, Kaisa Poutanen, Francesca Scazzina

Affiliations

  1. VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 VTT, Finland.
  2. Department of Food and Drug, University of Parma, via Volturno 39, 43125 Parma, Italy.
  3. Department of Animal Science, Food and Nutrition, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy.
  4. Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  5. Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
  6. Department of Medicine and Surgery, University of Parma, Parma, 43125, Italy.

PMID: 34669959 DOI: 10.1093/jn/nxab361

Abstract

BACKGROUND: Structure and protein-starch interactions in pasta products may be responsible for lower postprandial glycemic responses compared with other cereal foods.

OBJECTIVE: We tested the effect on postprandial glucose metabolism induced by two pasta products, couscous and bread, through their structural changes during mastication and simulated gastric digestion.

METHODS: Two randomized controlled trials (n = 30/trial) in healthy normal weight adults (23.9 and 23.0 kg/m2) evaluated postprandial glucose metabolism modulation to 50g of available carbohydrate portions of durum wheat semolina spaghetti, penne, couscous, and bread. A mastication trial involving 26 normal weight adults was conducted to investigate mastication processes and changes in particle size distribution and microstructure (light microscopy) of boluses after mastication and in vitro gastric digestion.

RESULTS: Both pasta products resulted in lower areas under the 2h-curve for blood glucose (-40% for spaghetti and -22% for penne vs couscous; -41% for spaghetti and -30% for penne vs bread), compared with the other grain products (P < 0.05). Pasta products required more chews (spaghetti: 34 ± 18; penne: 38 ± 20;  bread: 27 ± 13; couscous: 24 ± 17) and longer oral processing (spaghetti: 21 ± 13 s; penne: 23 ± 14 s; bread: 18 ± 9 s; couscous: 14 ± 10 s) than bread or couscous (P < 0.01). Pastas contained more large particles (46-67% of total particle area) compared to bread (0-30%) and couscous (1%) after mastication and in vitro gastric digestion. After in vitro gastric digestion, pasta samples still contained large areas of non-hydrolyzed starch embedded within the protein network, protein in bread and couscous was almost entirely digested, and starch was hydrolyzed.

CONCLUSIONS: Preservation of the pasta structure during mastication and gastric digestion explains slower starch hydrolysis and, consequently, lower postprandial glycemia compared to bread or couscous prepared from the same durum wheat semolina flour in healthy adults. Postprandial in vivo trials were registered at clinicaltrials.gov as NCT03098017 & NCT03104686.Clinical Trial Registry: NCT03098017 & NCT03104686 www.clinicaltrials.gov.

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

Keywords: c-peptide response; food structure; glycemic response; insulin response; mastication

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