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Shan X, Zhang L, Ye H, et al. Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples. Bioanalysis. 2021;13(20):1569-1584doi: 10.4155/bio-2021-0180.
Shan, X., Zhang, L., Ye, H., Shao, J., Shi, Y., Tan, S., Zhang, L., & Su, K. (2021). Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples. Bioanalysis, 13(20), 1569-1584. https://doi.org/10.4155/bio-2021-0180
Shan, Xiaoyue, et al. "Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples." Bioanalysis vol. 13,20 (2021): 1569-1584. doi: https://doi.org/10.4155/bio-2021-0180
Shan X, Zhang L, Ye H, Shao J, Shi Y, Tan S, Zhang L, Su K. Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples. Bioanalysis. 2021 Oct;13(20):1569-1584. doi: 10.4155/bio-2021-0180. Epub 2021 Oct 26. PMID: 34696600.
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Bioanalysis. 2021 Oct;13(20):1569-1584. doi: 10.4155/bio-2021-0180. Epub 2021 Oct 26.

Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples.

Bioanalysis

Xiaoyue Shan, Lei Zhang, Haipeng Ye, Ji Shao, Yanpeng Shi, Siwei Tan, Ling Zhang, Kewen Su

Affiliations

  1. Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China.

PMID: 34696600 DOI: 10.4155/bio-2021-0180

Abstract

Quantification of hippuric acid and methylhippuric acid in human urine matrices provides information on the toluene and xylene exposure conditions. High performance liquid chromatography coupled with UV detection is the preferable technique for hippuric acid and methylhippuric acid detection in human urine. This study was conducted to present analytical techniques developed for monitoring of hippuric acid and methylhippuric acid in human urine matrices during 2016-2021.

Keywords: analytical techniques; hippuric acid; methyl hippuric acid; toluene; urine; xylene

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