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Eur Heart J Cardiovasc Imaging. 2021 Nov 03; doi: 10.1093/ehjci/jeab154. Epub 2021 Nov 03.

Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging.

European heart journal. Cardiovascular Imaging

Otto A Smiseth, Daniel A Morris, Nuno Cardim, Maja Cikes, Victoria Delgado, Erwan Donal, Frank A Flachskampf, Maurizio Galderisi, Bernhard L Gerber, Alessia Gimelli, Allan L Klein, Juhani Knuuti, Patrizio Lancellotti, Julia Mascherbauer, Davor Milicic, Petar Seferovic, Scott Solomon, Thor Edvardsen, Bogdan A Popescu,

Affiliations

  1. Department of Cardiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.
  2. Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.
  3. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  4. Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
  5. Cardiology Department, Hospital da Luz, Av. Lusíada, N° 100, Lisbon, Portugal.
  6. Department of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia.
  7. Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, Leiden 2300 RC, The Netherlands.
  8. Service de Cardiologie Et Maladies Vasculaires Et CIC-IT 1414, CHU Rennes, 35000 Rennes, France.
  9. Université de Rennes 1, LTSI, 35000 Rennes, France.
  10. Department of Medical Sciences, Clinical Physiology and Cardiology, Uppsala University Hospital, Uppsala, Sweden.
  11. Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  12. Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc, Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Av Hippocrate, 10/2806 Brussels, Belgium.
  13. Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, Pisa 56124, Italy.
  14. Section of Cardiovascular Imaging, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
  15. Turku PET Centre, University of Turku, and Turku University Hospital, Turku, Finland.
  16. Department of Cardiology, University of Liège Hospital, Domaine Universitaire du Sart Tilman, Liège B4000, Belgium.
  17. Gruppo Villa Maria Care and Research, Maria Cecilia Hospital, Cotignola, and Anthea Hospital, Bari, Italy.
  18. Department of Internal Medicine 3, Karl Landsteiner University of Health Sciences, University Hospital St. Pölten, Krems, Austria.
  19. Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia.
  20. Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  21. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  22. Department of Cardiology, University of Medicine and Pharmacy "Carol Davila", Euroecolab, Emergency Institute for Cardiovascular Diseases "Prof. Dr. C. C. Iliescu", Sos. Fundeni 258, sector 2, 022328 Bucharest, Romania.

PMID: 34729586 DOI: 10.1093/ehjci/jeab154

Abstract

Nearly half of all patients with heart failure (HF) have a normal left ventricular (LV) ejection fraction (EF) and the condition is termed heart failure with preserved ejection fraction (HFpEF). It is assumed that in these patients HF is due primarily to LV diastolic dysfunction. The prognosis in HFpEF is almost as severe as in HF with reduced EF (HFrEF). In contrast to HFrEF where drugs and devices are proven to reduce mortality, in HFpEF there has been limited therapy available with documented effects on prognosis. This may reflect that HFpEF encompasses a wide range of different pathological processes, which multimodality imaging is well placed to differentiate. Progress in developing therapies for HFpEF has been hampered by a lack of uniform diagnostic criteria. The present expert consensus document from the European Association of Cardiovascular Imaging (EACVI) provides recommendations regarding how to determine elevated LV filling pressure in the setting of suspected HFpEF and how to use multimodality imaging to determine specific aetiologies in patients with HFpEF.

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: [email protected].

Keywords: diastole; echocardiography; filling pressure; heart failure; multimodality imaging

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