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Nzuza N, Padayachee T, Chen W, et al. Diversification of Ferredoxins across Living Organisms. Curr Issues Mol Biol. 2021;43(3):1374-1390doi: 10.3390/cimb43030098.
Nzuza, N., Padayachee, T., Chen, W., Gront, D., Nelson, D. R., & Syed, K. (2021). Diversification of Ferredoxins across Living Organisms. Current issues in molecular biology, 43(3), 1374-1390. https://doi.org/10.3390/cimb43030098
Nzuza, Nomfundo, et al. "Diversification of Ferredoxins across Living Organisms." Current issues in molecular biology vol. 43,3 (2021): 1374-1390. doi: https://doi.org/10.3390/cimb43030098
Nzuza N, Padayachee T, Chen W, Gront D, Nelson DR, Syed K. Diversification of Ferredoxins across Living Organisms. Curr Issues Mol Biol. 2021 Sep 30;43(3):1374-1390. doi: 10.3390/cimb43030098. PMID: 34698119.
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Curr Issues Mol Biol. 2021 Sep 30;43(3):1374-1390. doi: 10.3390/cimb43030098.

Diversification of Ferredoxins across Living Organisms.

Current issues in molecular biology

Nomfundo Nzuza, Tiara Padayachee, Wanping Chen, Dominik Gront, David R Nelson, Khajamohiddin Syed

Affiliations

  1. Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
  2. Department of Molecular Microbiology and Genetics, University of Göttingen, 37077 Göttingen, Germany.
  3. Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
  4. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

PMID: 34698119 DOI: 10.3390/cimb43030098

Abstract

Ferredoxins, iron-sulfur (Fe-S) cluster proteins, play a key role in oxidoreduction reactions. To date, evolutionary analysis of these proteins across the domains of life have been confined to observing the abundance of Fe-S cluster types (2Fe-2S, 3Fe-4S, 4Fe-4S, 7Fe-8S (3Fe-4s and 4Fe-4S) and 2[4Fe-4S]) and the diversity of ferredoxins within these cluster types was not studied. To address this research gap, here we propose a subtype classification and nomenclature for ferredoxins based on the characteristic spacing between the cysteine amino acids of the Fe-S binding motif as a subtype signature to assess the diversity of ferredoxins across the living organisms. To test this hypothesis, comparative analysis of ferredoxins between bacterial groups,

Keywords: Archaea; Bacteria; Eukarya; domains of life; evolution; ferredoxins; iron-sulfur proteins; lateral gene transfer

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Grant support