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Pierman G, Delgrange E, Jonas C. Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?. Eur J Case Rep Intern Med. 2021;8(9):002807doi: 10.12890/2021_002807.
Pierman, G., Delgrange, E., & Jonas, C. (2021). Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?. European journal of case reports in internal medicine, 8(9), 002807. https://doi.org/10.12890/2021_002807
Pierman, Guillaume, et al. "Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?." European journal of case reports in internal medicine vol. 8,9 (2021): 002807. doi: https://doi.org/10.12890/2021_002807
Pierman G, Delgrange E, Jonas C. Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?. Eur J Case Rep Intern Med. 2021 Sep 02;8(9):002807. doi: 10.12890/2021_002807. eCollection 2021. PMID: 34671577; PMCID: PMC8523378.
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Eur J Case Rep Intern Med. 2021 Sep 02;8(9):002807. doi: 10.12890/2021_002807. eCollection 2021.

Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?.

European journal of case reports in internal medicine

Guillaume Pierman, Etienne Delgrange, Corinne Jonas

Affiliations

  1. Department of Endocrinology, Centre Hospitalier Universitaire de Mont-Godinne, Yvoir, Belgium.

PMID: 34671577 PMCID: PMC8523378 DOI: 10.12890/2021_002807

Abstract

Graves' disease is the most frequent cause of hyperthyroidism in young women. This auto-immune disease is due to the production of class 1 IgG stimulating the TSH receptor. These antibodies are produced secondary to a Th1 immune response in which interferon gamma plays a key role. Vaccination is ongoing worldwide against SARS-CoV-2 and some of the vaccines include mRNA which seems to stimulate the Th1 immune response. Here, we report a case of recurrence of hyperthyroidism due to Graves' disease following mRNA vaccination and discuss the possible implicated mechanism. This observation argues for a systematic study of a population of patients with previous Graves' disease in order to assess the risk of recurrence following vaccination.

LEARNING POINTS: Graves' disease is a Th1-mediated immune disease in which interferon gamma plays a key role.The recurrence of hyperthyroidism due to Grave's disease should be monitored in patients exposed to risk factors.

© EFIM 2021.

Keywords: Graves’ disease; Hyperthyroidism; SARS-CoV-2; vaccine

Conflict of interest statement

Conflicts of Interests: The authors declare there are no competing interests.

References

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