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Jayant K, Reccia I, Bachul PJ, et al. The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis. J Clin Med. 2021;10(19)doi: 10.3390/jcm10194533.
Jayant, K., Reccia, I., Bachul, P. J., Al-Salmay, Y., Pyda, J. S., Podda, M., Perez-Gutierrez, A., Dor, F. J. M. F., Becker, Y., di Sabato, D., LaMattina, J., Barth, R., Fung, J., & Witkowski, P. (2021). The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis. Journal of clinical medicine, 10(19), . https://doi.org/10.3390/jcm10194533
Jayant, Kumar, et al. "The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis." Journal of clinical medicine vol. 10,19 (2021). doi: https://doi.org/10.3390/jcm10194533
Jayant K, Reccia I, Bachul PJ, Al-Salmay Y, Pyda JS, Podda M, Perez-Gutierrez A, Dor FJMF, Becker Y, di Sabato D, LaMattina J, Barth R, Fung J, Witkowski P. The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis. J Clin Med. 2021 Sep 30;10(19). doi: 10.3390/jcm10194533. PMID: 34640552; PMCID: PMC8509345.
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J Clin Med. 2021 Sep 30;10(19). doi: 10.3390/jcm10194533.

The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis.

Journal of clinical medicine

Kumar Jayant, Isabella Reccia, Piotr J Bachul, Yaser Al-Salmay, Jordan S Pyda, Mauro Podda, Angelica Perez-Gutierrez, Frank J M F Dor, Yolanda Becker, Diego di Sabato, John LaMattina, Rolf Barth, John Fung, Piotr Witkowski

Affiliations

  1. Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  2. Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
  3. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  4. Department of Emergency Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University Hospital Policlinico Duilio Casula, 09124 Cagliari, Italy.
  5. Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK.

PMID: 34640552 PMCID: PMC8509345 DOI: 10.3390/jcm10194533

Abstract

Herein, we performed a meta-analysis of published clinical outcomes of corona virus disease 2019 (COVID-19) in hospitalized kidney transplant recipients. A systematic database search was conducted between December 1, 2019 and April 20, 2020. We analyzed 48 studies comprising 3137 kidney transplant recipients with COVID-19. Fever (77%), cough (65%), dyspnea (48%), and gastrointestinal symptoms (28%) were predominant on hospital admission. The most common comorbidities were hypertension (83%), diabetes mellitus (34%), and cardiac disease (23%). The pooled prevalence of acute respiratory distress syndrome and acute kidney injury were 58% and 48%, respectively. Invasive ventilation and dialysis were required in 24% and 22% patients, respectively. In-hospital mortality rate was as high as 21%, and increased to over 50% for patients in intensive care unit (ICU) or requiring invasive ventilation. Risk of mortality in patients with acute respiratory distress syndrome (ARDS), on mechanical ventilation, and ICU admission was increased: OR = 19.59, OR = 3.80, and OR = 13.39, respectively. Mortality risk in the elderly was OR = 3.90; however, no such association was observed in terms of time since transplantation and gender. Fever, cough, dyspnea, and gastrointestinal symptoms were common on admission for COVID-19 in kidney transplant patients. Mortality was as high as 20% and increased to over 50% in patients in ICU and required invasive ventilation.

Keywords: COVID-19; SARS-CoV-2; kidney transplantation

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