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Medina-Diaz-Cortés G, Brancaccio-Pérez IV, Esparza-Estrada I, et al. Differences in Postoperative Pain, Nausea, and Vomiting After Elective Laparoscopic Cholecystectomy in Premenopausal and Postmenopausal Mexican Women. World J Surg. 2021;doi: 10.1007/s00268-021-06367-y.
Medina-Diaz-Cortés, G., Brancaccio-Pérez, I. V., Esparza-Estrada, I., Barbosa-Camacho, F. J., Fuentes-Orozco, C., González-Hernández, P. G., Chejfec-Ciociano, J. M., Ramírez-Sánchez, M. V., Sánchez-López, V. A., Cortés-Flores, A. O., Álvarez-Villaseñor, A. S., Chávez-Tostado, M., Cervantes-Pérez, E., Cervantes-Guevara, G., Cervantes-Cardona, G. A., & González-Ojeda, A. (2021). Differences in Postoperative Pain, Nausea, and Vomiting After Elective Laparoscopic Cholecystectomy in Premenopausal and Postmenopausal Mexican Women. World journal of surgery, . https://doi.org/10.1007/s00268-021-06367-y
Medina-Diaz-Cortés, Guillermo, et al. "Differences in Postoperative Pain, Nausea, and Vomiting After Elective Laparoscopic Cholecystectomy in Premenopausal and Postmenopausal Mexican Women." World journal of surgery vol. (2021). doi: https://doi.org/10.1007/s00268-021-06367-y
Medina-Diaz-Cortés G, Brancaccio-Pérez IV, Esparza-Estrada I, Barbosa-Camacho FJ, Fuentes-Orozco C, González-Hernández PG, Chejfec-Ciociano JM, Ramírez-Sánchez MV, Sánchez-López VA, Cortés-Flores AO, Álvarez-Villaseñor AS, Chávez-Tostado M, Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Cardona GA, González-Ojeda A. Differences in Postoperative Pain, Nausea, and Vomiting After Elective Laparoscopic Cholecystectomy in Premenopausal and Postmenopausal Mexican Women. World J Surg. 2021 Nov 03; doi: 10.1007/s00268-021-06367-y. Epub 2021 Nov 03. PMID: 34731260.
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World J Surg. 2021 Nov 03; doi: 10.1007/s00268-021-06367-y. Epub 2021 Nov 03.

Differences in Postoperative Pain, Nausea, and Vomiting After Elective Laparoscopic Cholecystectomy in Premenopausal and Postmenopausal Mexican Women.

World journal of surgery

Guillermo Medina-Diaz-Cortés, Irma Valeria Brancaccio-Pérez, Isaac Esparza-Estrada, Francisco José Barbosa-Camacho, Clotilde Fuentes-Orozco, Paola Guadalupe González-Hernández, Jonathan Matías Chejfec-Ciociano, Marco Vinicio Ramírez-Sánchez, Veronica Alexandra Sánchez-López, Ana Olivia Cortés-Flores, Andrea Socorro Álvarez-Villaseñor, Mariana Chávez-Tostado, Enrique Cervantes-Pérez, Gabino Cervantes-Guevara, Guillermo Alonso Cervantes-Cardona, Alejandro González-Ojeda

Affiliations

  1. Biomedical Research Unit 02. Specialties Hospital, Western Medical Center, Mexican Institute of Social Security, Avenida Belisario Domínguez 1000, 44430, Guadalajara, Jalisco, Mexico.
  2. Medical Auxiliary Coordination of Health Research, Mexican Institute of Social Security, Calle Francisco I. Madero 315, 23020, La Paz, Baja California Sur, Mexico.
  3. Department of Human Reproduction, Health Sciences University Center, Universidad de Guadalajara, Calle Hospital 320, 44280, Guadalajara, Jalisco, Mexico.
  4. Department of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Calle Hospital 278, 44280, Guadalajara, Jalisco, Mexico.
  5. Department of Welfare and Sustainable Development, University Center of the North, University of Guadalajara, Carretera Federal 23, Km 191, 46200, Colotlán, Jalisco, Mexico.
  6. Department of Philosophical, Methodological and Instrumental Disciplines, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, 44340, Guadalajara, Jalisco, Mexico.
  7. Biomedical Research Unit 02. Specialties Hospital, Western Medical Center, Mexican Institute of Social Security, Avenida Belisario Domínguez 1000, 44430, Guadalajara, Jalisco, Mexico. [email protected].

PMID: 34731260 DOI: 10.1007/s00268-021-06367-y

Abstract

BACKGROUND: Postoperative symptoms and pain after laparoscopic cholecystectomy (LC) are common in women. However, there is no evidence of differences in incidence and severity among different age groups. We evaluated whether adverse postoperative symptoms were more common in younger than in older women after LC.

METHODS: One hundred and fifty premenopausal (mean age 37.6 ± 3.6 y) and 145 postmenopausal women (59 ± 5.2 y) were included in this retrospective cohort study. Clinical and anthropometric parameters were analyzed. Study endpoints were the incidences of postoperative nausea and vomiting (PONV) and pain, and the additional analgesics and antiemetics needed after surgery.

RESULTS: Body mass index was normal in 42.7% of patients in the younger group and 64.8% in the older group (P < 0.001). Reported pain was more frequent and intense in the younger group throughout the study period (P < 0.01). Additional narcotics were required in 18% of premenopausal versus 7.6% of postmenopausal women (P = 0.001), and the doses used to reduce pain were higher for premenopausal women (P = 0.02). PONV was more frequent in the younger group at 1 and 6 h after surgery (P < 0.005). Rescue antiemetics were required in 29 premenopausal and 13 postmenopausal women (P = 0.01). Hospital stay was shorter for the older patients (P = 0.01). Minor morbidity was observed in both groups (0.7% and 2.1%). There was no mortality.

CONCLUSIONS: Early PONV and pain after LC were more frequent in premenopausal women, who also required more rescue analgesic and antiemetic medication.

© 2021. Société Internationale de Chirurgie.

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