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Gen Comp Endocrinol. 2022 Jan 01;315:113930. doi: 10.1016/j.ygcen.2021.113930. Epub 2021 Oct 19.

Mediatory role of the central NPY, melanocortine and corticotrophin systems on phoenixin-14 induced hyperphagia in neonatal chicken.

General and comparative endocrinology

Sahar Rajaei, Morteza Zendehdel, Mehdi Rahnema, Shahin Hassanpour, Masoumeh Asle-Rousta

Affiliations

  1. Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
  2. Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453 Tehran, Iran. Electronic address: [email protected].
  3. Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

PMID: 34673032 DOI: 10.1016/j.ygcen.2021.113930

Abstract

Animal research indicates the neuropeptide Y (NPY), corticotrophin and melanocortin systems have a mediatory role in reward, however, how these substances interact with phenytoin-14 (PNX-14) induced food intake in birds remains to be identified. Accordingly, in this research eight tests were carried out to investigate the potential interactions of the NPY, melanocortin, as well as corticotrophin systems with PNX-14 on food consumption in neonatal chickens. In the first experiment, chickens were intracerebroventricular (ICV) injected with phosphate-buffered saline (PBS) and PNX-14 (0.8, 0.16, and 3.2 nmol). In second experiment, PBS, the antagonist of CRF

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Corticotrophin; Food intake; Melanocortine; NPY; Neonatal chicken; Phoenixin-14

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