Display options
Cite
Sosa F, Carmickle AT, Jiménez-Cabán E, et al. Inheritance of the SLICK1 allele of PRLR in cattle. Anim Genet. 2021;52(6):887-890doi: 10.1111/age.13145.
Sosa, F., Carmickle, A. T., Jiménez-Cabán, E., Ortega, M. S., Dikmen, S., Negrón-Pérez, V., Jannaman, E. A., Baktula, A., Rincon, G., Larson, C. C., Pagán-Morales, M., Denicol, A. C., Sonstegard, T. S., & Hansen, P. J. (2021). Inheritance of the SLICK1 allele of PRLR in cattle. Animal genetics, 52(6), 887-890. https://doi.org/10.1111/age.13145
Sosa, F, et al. "Inheritance of the SLICK1 allele of PRLR in cattle." Animal genetics vol. 52,6 (2021): 887-890. doi: https://doi.org/10.1111/age.13145
Sosa F, Carmickle AT, Jiménez-Cabán E, Ortega MS, Dikmen S, Negrón-Pérez V, Jannaman EA, Baktula A, Rincon G, Larson CC, Pagán-Morales M, Denicol AC, Sonstegard TS, Hansen PJ. Inheritance of the SLICK1 allele of PRLR in cattle. Anim Genet. 2021 Dec;52(6):887-890. doi: 10.1111/age.13145. Epub 2021 Oct 12. PMID: 34642995.
Copy Download .nbib Format: NLM
Share it on

Anim Genet. 2021 Dec;52(6):887-890. doi: 10.1111/age.13145. Epub 2021 Oct 12.

Inheritance of the SLICK1 allele of PRLR in cattle.

Animal genetics

F Sosa, A T Carmickle, E Jiménez-Cabán, M S Ortega, S Dikmen, V Negrón-Pérez, E A Jannaman, A Baktula, G Rincon, C C Larson, M Pagán-Morales, A C Denicol, T S Sonstegard, P J Hansen

Affiliations

  1. Department of Animal Sciences, University of Florida, Gainesville, FL, 32611-0910, USA.
  2. Department of Animal Science, University of California, Davis, CA, 95616, USA.
  3. Department of Animal Science, University of Puerto Rico-Mayagüez, Mayagüez, PR, 00680, USA.
  4. Division of Animal Sciences, University of Missouri, Columbia, MI, 65211, USA.
  5. Department of Animal Science, Faculty of Veterinary Medicine, Bursa Uluda? University, Bursa, 16059, Turkey.
  6. Zoetis, Kalamazoo, MI, 49007, USA.
  7. Okeechobee County Cooperative Extension Service, University of Florida/Institute of Food and Agricultural Sciences, Okeechobee, FL, 34972, USA.
  8. Acceligen, Eagan, MN, 55121, USA.

PMID: 34642995 DOI: 10.1111/age.13145

Abstract

The slick-hair phenotype in cattle is due to one of a series of mutations in the prolactin receptor (PRLR) that cause truncation of the C-terminal region of the protein involved in JAK2/STAT5 activation during prolactin signaling. Here we evaluated whether the inheritance of the SLICK1 allele, the first slick mutation discovered, is inherited in a fashion consistent with Hardy-Weinberg equilibrium. It was hypothesized that any deleterious effect of inheriting the allele on embryonic or fetal function would result in reduced frequency of the allele in offspring. A total of 525 Holstein and Senepol cattle produced from matings involving one or both parents with the SLICK1 allele were genotyped. The observed frequency of the SLICK1 allele (0.247) was not significantly different than the expected frequency of 0.269. These results support the idea that inheritance of the SLICK1 allele does not act in the embryo or fetus to modify its competence to complete development to term.

© 2021 Stichting International Foundation for Animal Genetics.

Keywords: Prolactin receptor; cattle; slick mutation; thermotolerance

References

  1. Biener E., Martin C., Daniel N., Frank S.J., Centonze V.E., Herman B., Djiane J. & Gertler A. (2003) Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3. Endocrinology 144, 3532-40. - PubMed
  2. Bole-Feysot C., Goffin V., Edery M., Binart N. & Kelly P.A. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocrine Reviews 19, 225-68. - PubMed
  3. Brooks C.L. (2012) Molecular mechanisms of prolactin and its receptor. Endocrine Reviews 33, 504-25. - PubMed
  4. Dikmen S., Khan F.A., Huson H.J., Sonstegard T.S., Moss J.I., Dahl G.E. & Hansen P.J. (2014) The SLICK hair locus derived from Senepol cattle confers thermotolerance to intensively managed lactating Holstein cows. Journal of Dairy Science 97, 5508-20. - PubMed
  5. Flórez Murillo J.M., Landaeta-Hernández A.J., Kim E.S., Bostrom J.R., Larson S.A., Pérez O'Brien A.M., Montero-Urdaneta M.A., Garcia J.F. & Sonstegard T.S. (2021) Three novel nonsense mutations of prolactin receptor found in heat-tolerant Bos taurus breeds of the Caribbean Basin. Animal Genetics 52, 132-4. - PubMed
  6. Goffin V. & Kelly P.A. (1996) Prolactin and growth hormone receptors. Clinical Endocrinology 45, 247-55. - PubMed
  7. He C., Holme J. & Anthony J. (2014) SNP genotyping: the KASP assay. Methods in Molecular Biology 1145, 75-86. - PubMed
  8. Littlejohn M.D., Henty K.M., Tiplady K. et␣al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle. Nature Communications 5, 5861. - PubMed
  9. Olson T.A., Lucena C., Chase C.C. Jr & Hammond A.C. (2003) Evidence of a major gene influencing hair length and heat tolerance in Bos taurus cattle. Journal of Animal Science 81, 80-90. - PubMed
  10. Ortiz-Colón G., Fain S.J., Parés I.K., Curbelo-Rodríguez J., Jiménez-Cabán E., Pagán-Morales M. & Gould M.A. (2018) Assessing climate vulnerabilities and adaptive strategies for resilient beef and dairy operations in the tropics. Climate Change 146, 47-58. - PubMed
  11. Porto-Neto L.R., Bickhart D.M., Landaeta-Hernandez A.J. et␣al. (2018) Convergent evolution of slick coat in cattle through truncation mutations in the prolactin receptor. Frontiers in Genetics 9, 57. - PubMed

Publication Types

Grant support