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Adv Funct Mater. 2021 Sep 09;31(37). doi: 10.1002/adfm.202101005. Epub 2021 Jun 17.

Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques.

Advanced functional materials

Mahsa Gifani, Devon J Eddins, Hisanori Kosuge, Yapei Zhang, Sesha L A Paluri, Timothy Larson, Nicholas Leeper, Leonore A Herzenberg, Sanjiv Sam Gambhir, Michael V McConnell, Eliver E B Ghosn, Bryan Ronain Smith

Affiliations

  1. Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
  2. Departments of Medicine and Pediatrics, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA.
  3. Division of Cardiovascular Medicine and Vascular Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  4. Departments of Radiology, Bioengineering, and Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.
  5. Department of Genetics, Stanford University, Stanford, CA 94305, USA.

PMID: 34733130 PMCID: PMC8559995 DOI: 10.1002/adfm.202101005

Abstract

Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method that detects high-risk atherosclerotic plaques at early stages could prevent these sequelae. The abundance of immune cells in the arterial wall, especially inflammatory Ly-6C

Keywords: atherosclerosis; carbon nanotubes; diagnostic imaging; flow cytometry; immunoimaging; photoacoustic imaging

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