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Haraldsdottir A, Steingrimsdottir L, Maskarinec G, et al. Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study. Am J Epidemiol. 2021;doi: 10.1093/aje/kwab250.
Haraldsdottir, A., Steingrimsdottir, L., Maskarinec, G., Adami, H. O., Aspelund, T., Valdimarsdottir, U. A., Bjarnason, R., Thorsdottir, I., Halldorsson, T. I., Gunnarsdottir, I., Tryggvadottir, L., Gudnason, V., Birgisdottir, B. E., & Torfadottir, J. E. (2021). Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study. American journal of epidemiology, . https://doi.org/10.1093/aje/kwab250
Haraldsdottir, Alfheidur, et al. "Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study." American journal of epidemiology vol. (2021). doi: https://doi.org/10.1093/aje/kwab250
Haraldsdottir A, Steingrimsdottir L, Maskarinec G, Adami HO, Aspelund T, Valdimarsdottir UA, Bjarnason R, Thorsdottir I, Halldorsson TI, Gunnarsdottir I, Tryggvadottir L, Gudnason V, Birgisdottir BE, Torfadottir JE. Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study. Am J Epidemiol. 2021 Oct 13; doi: 10.1093/aje/kwab250. Epub 2021 Oct 13. PMID: 34643238.
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Am J Epidemiol. 2021 Oct 13; doi: 10.1093/aje/kwab250. Epub 2021 Oct 13.

Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study.

American journal of epidemiology

Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Gertraud Maskarinec, Hans-Olov Adami, Thor Aspelund, Unnur A Valdimarsdottir, Ragnar Bjarnason, Inga Thorsdottir, Thorhallur I Halldorsson, Ingibjorg Gunnarsdottir, Laufey Tryggvadottir, Vilmundur Gudnason, Bryndis E Birgisdottir, Johanna E Torfadottir

Affiliations

  1. Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  2. Faculty of Food Science and Human Nutrition, University of Iceland, Reykjavik, Iceland.
  3. Unit for Nutrition Research, University of Iceland and Landspitali National University Hospital, Reykjavik, Iceland.
  4. University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
  5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  6. Clinical Effectiveness Research Group, Institute of Health, University of Oslo, Oslo, Norway.
  7. Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, Massachusetts, United States of America.
  8. Children's Medical Center, Landspitali National University Hospital, Reykjavik, Iceland.
  9. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  10. School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  11. Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen S, Denmark.
  12. Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland.
  13. The Icelandic Heart Association, Kopavogur, Iceland.

PMID: 34643238 DOI: 10.1093/aje/kwab250

Abstract

Growth rate is regulated by hormonal pathways that might affect early cancer development. We explored the association between rate of growth in height from age 8 to 13 (childhood) years and from age 13 to height at study entry (adolescence), and risk of breast and prostate cancer. Participants were 2,037 Icelanders born 1915 - 1935, who took part in the Reykjavik Study established 1967. Height measures were obtained from school records and at study entry. We used multivariable Cox regression models to calculate hazard ratios with 95% confidence intervals of breast and prostate cancer by rates of growth in tertiles. During a mean follow-up of 66 years (women) and 64 years (men), 117 women were diagnosed with breast cancer and 118 men with prostate cancer (45 w/advanced). Women in the highest tertile of growth rate in adolescence had increased risk of breast cancer, hazard ratio 2.4, 95% confidence interval: 1.3, 4.3, compared with women in the lowest tertile. A suggestive inverse association was observed for highest adolescent rate of growth in men and advanced prostate cancer, hazard ratio 0.4, 95% confidence interval: 0.2, 1.0. Rapid growth, particularly in adolescence may affect cancer risk later in life.

© The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Breast cancer; adolescence; childhood; growth rate; height; prostate cancer

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