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Pouget C, Dunyach-Remy C, Pantel A, et al. Alternative Approaches for the Management of Diabetic Foot Ulcers. Front Microbiol. 2021;12:747618doi: 10.3389/fmicb.2021.747618.
Pouget, C., Dunyach-Remy, C., Pantel, A., Boutet-Dubois, A., Schuldiner, S., Sotto, A., Lavigne, J. P., & Loubet, P. (2021). Alternative Approaches for the Management of Diabetic Foot Ulcers. Frontiers in microbiology, 12747618. https://doi.org/10.3389/fmicb.2021.747618
Pouget, Cassandra, et al. "Alternative Approaches for the Management of Diabetic Foot Ulcers." Frontiers in microbiology vol. 12 (2021): 747618. doi: https://doi.org/10.3389/fmicb.2021.747618
Pouget C, Dunyach-Remy C, Pantel A, Boutet-Dubois A, Schuldiner S, Sotto A, Lavigne JP, Loubet P. Alternative Approaches for the Management of Diabetic Foot Ulcers. Front Microbiol. 2021 Oct 05;12:747618. doi: 10.3389/fmicb.2021.747618. eCollection 2021. PMID: 34675910; PMCID: PMC8524042.
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Front Microbiol. 2021 Oct 05;12:747618. doi: 10.3389/fmicb.2021.747618. eCollection 2021.

Alternative Approaches for the Management of Diabetic Foot Ulcers.

Frontiers in microbiology

Cassandra Pouget, Catherine Dunyach-Remy, Alix Pantel, Adeline Boutet-Dubois, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Paul Loubet

Affiliations

  1. Virulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, Nîmes, France.
  2. Virulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, Service de Microbiologie et Hygiène Hospitalière, Clinique du Pied Gard Occitanie, CHU Nîmes, Nîmes, France.
  3. Virulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, Service des Maladies Métaboliques et Endocriniennes, Clinique du Pied Gard Occitanie, CHU Nîmes, Le Grau-du-Roi, France.
  4. Virulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, Service des Maladies Infectieuses et Tropicales, Clinique du Pied Gard Occitanie, CHU Nîmes, Nîmes, France.

PMID: 34675910 PMCID: PMC8524042 DOI: 10.3389/fmicb.2021.747618

Abstract

Diabetic foot ulcers (DFU) represent a growing public health problem. The emergence of multidrug-resistant (MDR) bacteria is a complication due to the difficulties in distinguishing between infection and colonization in DFU. Another problem lies in biofilm formation on the skin surface of DFU. Biofilm is an important pathophysiology step in DFU and may contribute to healing delays. Both MDR bacteria and biofilm producing microorganism create hostile conditions to antibiotic action that lead to chronicity of the wound, followed by infection and, in the worst scenario, lower limb amputation. In this context, alternative approaches to antibiotics for the management of DFU would be very welcome. In this review, we discuss current knowledge on biofilm in DFU and we focus on some new alternative solutions for the management of these wounds, such as antibiofilm approaches that could prevent the establishment of microbial biofilms and wound chronicity. These innovative therapeutic strategies could replace or complement the classical strategy for the management of DFU to improve the healing process.

Copyright © 2021 Pouget, Dunyach-Remy, Pantel, Boutet-Dubois, Schuldiner, Sotto, Lavigne and Loubet.

Keywords: alternative therapeutic approaches; antibiofilm; biofilm; chronic wound; diabetic foot

Conflict of interest statement

CP is the recipient of a grant from Biofilm Control (Bourse CIFRE). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could

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