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Vet Dermatol. 1999 Sep;10(3):217-223. doi: 10.1046/j.1365-3164.1999.00176.x.

Macrolides and lincosamides.

Veterinary dermatology

C Noli, D Boothe

Affiliations

  1. Studio Dermatologico Veterinario, Via Sismondi 62, 20133, Milano, Italy.
  2. Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843-4466, USA.

PMID: 34644913 DOI: 10.1046/j.1365-3164.1999.00176.x

Abstract

Macrolides and lincosamides are first choice bacteriostatic antibiotics used in veterinary dermatology. The main antibiotics in these classes are erythromycin, lincomycin, clindamycin and tylosin. They are well absorbed if given orally and are able to penetrate well into infected skin. Their spectrum of action comprises bacteria commonly associated with skin infections, including staphylococci. Their main disadvantages are the rapid development of bacterial resistance and occasional gastroenteric upset, most often seen with erythromycin. More recently developed macrolides, such as azithromycin and clarithomycin, are bactericidal, have a larger spectrum of action, a longer endurance, less resistance and may be given once a day instead of two or three times daily.

Blackwell Science Ltd.

Keywords: cat; clindamycin; dog; erythromycin; lincomycin; lincosamides; macrolides; pyoderma; skin; tylosin

References

  1. Noble, W.C. Bacterial skin infections in domestic animals and man. In: Von Tscharner, C., Halliwell, R.E.W. eds. Advances in Veterinary Dermatology, Vol. 1. London: Ballière Tindall, 1990: 311 26. - PubMed
  2. Spoo, W. & Riviere, J. Chloramphenicol. In: Adams, R. ed. Veterinary Pharmacology and Therapeutics. Ames, Iowa: Iowa State University Press, 1995: 820 54. - PubMed
  3. Kapusnik-Uner, J.E., Sande, M.A, Chambers, H.F. Tetracyclines, chloramphenicol, erythromycin and miscellaneous antibacterial agents. In: Hardman, J.G., Limbird, L.E. eds. Goodman and Gilman’s the Pharmacologic Basis of Therapeutics, 9th edn. New York: McGraw-Hill, 1996: 1123 54. - PubMed
  4. Hunter, R.P., Lynch, M.J, Ericson, J.F. et al.Pharmacokinetics, oral bioavailability and tissue distribution of azithromycin in cats. Journal of Veter-inary Pharmacology and Therapeutics 1995; 18: 38 46. - PubMed
  5. Shepard, R.M. & Falkner, F.C. Pharmacokinetics of azithromycin in rats and dogs. Journal of Antimicrobial Chemotherapy 1990; 25(Suppl. A): 49 60. - PubMed
  6. Scott, D.W., Beningo, K.E., Miller, W.H., Rothstein, E. Efficacy of clindamycin hydrochloride capsules for the treatment of deep pyoderma due to Staphylococcus intermedius infection in dogs. Canadian Veterinary Journal 1998; 39: 753 6. - PubMed
  7. Keane, D.P. Chronic abscesses in cats associated with an organism resembling mycoplasma. Canadian Veterinary Journal 1983; 24: 289. - PubMed
  8. Carro, T., Pedersen, N.C., Beaman, B.L., Munn, R. Subcutaneous absecesses and arthritis caused by probable bacterial L-form in cats. Journal of the American Veterinary Medical Association 1989; 194: 1583 8. - PubMed
  9. Burrows, G.E. Pharmacotherapeutics of macrolides: lincomycins and spectinomycin. Journal of the American Veterinary Medical Association 1980; 176: 1072 7. - PubMed
  10. Pecherau, D., Martel, PH., Valognes, A., Pedaille, F., Kratz, A. Abcès sous-cutanés et plaies infectées chez le chat. Bactériologie et efficacité clinique de la clindamycine. Pratique Médicale et Chirurgicale Des Animaux de Compagnie 1995; 30: 99 103 (in French). - PubMed
  11. Scott, D.W., Miller, W.H., Griffin, C.E. Small Animal Dermatology, 5th edn. Philadelphia: W.B. Saunders, 1995: 219. - PubMed
  12. Kwochka, K.W. Recurrent Pyoderma. In: Griffin, C.E., Kwochka, K.W., MacDonald, J.M. eds. Current Veterinary Dermatology. St. Louis: Mosby Year Book, 1993: 3 21. - PubMed
  13. Perret, G., Yin, Y.L., Nicolas, P., Vassy, R., Uzzan, B., Louchahi, M. In vivo effects of macrolides on thyroid hormone serum levels and on hepatic type1, 5’deiodinase in rat. A comparative study with amiodarone, phenobarbital and propanolol. Fundaments in Clinical Pharmacology 1991; 5: 583 93. - PubMed
  14. Harvey, R.G. Tylosin in the treatment of canine superficial pyoderma. Veterinary Record 1996; 139: 185 7. - PubMed
  15. Scott, D.W., Miller, W.H., Cayatte, S.M., Bagladi, M.S. Efficacy of tylosin tablets for the treatment of pyoderma due to Staphylococcus intermedius infection in dogs. Canadian Veterinary Journal 1994; 35: 617 21. - PubMed
  16. Scott, D.W., Miller, W.H., Rothstein, S.E., Bagladi, M.S. Further studies on the effciacy of tylosin tablets for the treatment of pyoderma due to Staphylococcus intermedius infection in dogs. Canadian Veterinary Journal 1996; 37: 617 8. - PubMed
  17. Sampson, G.R., Sauter, R.A., Gregory, R.P. Clinical appraisal of tylosin in dogs. Veterinary Medicine Small Animal Clinics 1974; 69: 1259 62. - PubMed
  18. Prost, C. & Arfi, L. Utilisation de la lincomycine dans le traitement des pyodermites du chien. Pratique Médicale et Chirurgicale Des Animaux de Compagnie 1993; 28: 495 8 (in French). - PubMed
  19. Littlewood, J.D., Lakhani, K.H., Paterson, S., Wood, J.L.N., Chanter, N. Clindamycin hydrochloride and clavulanate-amoxycillin in the treatment of canine superficial pyoderma: A masked randomised con-trolled clinical trial. Veterinary Record 1999; 114: 662 5. - PubMed
  20. Piscitelli, S.C., Danziger, L.H., Rodvold, K.A. Clarithromycin and azithromycin: new macrolide antibiotics. Clinical Pharmacology 1992; 11: 137 52. - PubMed
  21. Daniel, R. Azithromycin, erythromycin and cloxacillin in the treatment of infections of skin and associated soft tissues. European Azithromycin Study Group. Journal of Internal Medicine Research 1991; 19: 433 45. - PubMed
  22. Rodriguez-Solares, A., Perez-Gutierrez, F, Prosperi, J., Milagram, E., Martin, A. A comparative study on the efficacy, safety and tolerance of azithromycin, diclox-acillin and flucloxacillin in the treatment of children with acute skin and skin-structure infections. Journal of Antimicrobial Chemotherapy 1993; 31(Suppl. E): 103 9. - PubMed
  23. Mallory, S.B. Azithromycin compared with cephalexin in the treatment of skin and skin structure infections. American Journal of Medicine 1991; 91(Suppl. 3A): 36 39. - PubMed
  24. McDonald, P.J. & Pruul, H. Phagocyte uptake and transport of azithromycin. European Journal of Clinical Microbiology and Infectious Diseases 1991; 10: 828 33. - PubMed
  25. Wildfeuer, A., Laufen, H., Muller-Wening, D., Haferkamp, O. Interaction of azithromycin and human phagocytic cells. Uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes. Arzneimittelforschung 1989; 39: 755 8. - PubMed
  26. Silvestri, M., Oddera, S., Eftimiadi, C., Rossi, G.A. Azithromycin induces in vitro a time-dependent increase in the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes without damaging phagocytes. Journal of Antimicrobial Chemotherapy 1995; 36: 941 50. - PubMed
  27. Tufano, M.A., De Cipollaro l’Ero, G., Ianniello, R., Baroni, A., Galdiero, F. Antimicrobial agents induce monocytes to release IL-1 alpha, IL-6, and TNF, and induce lymphocytes to release IL-4 and TNF tau. Immunopharmacology and Immunotoxicology 1992; 14: 769 82. - PubMed
  28. Matsuoka, M., Endou, K., Nakajima, Y. Localization of a determinant mediating partial macrolide resistance in Staphylococcus Aureus. Microbiology and Immunology 1990; 34: 643 52. - PubMed
  29. Huovinen, P, Seppala, H., Kataja, J, Klaukka, T. & The Finnish Study Group for Antimicrobial Resistance. The relationship between erythromycin consumption and resistance in Finland. Ciba Foundation Symposium 1997; 207: 36 46. - PubMed
  30. Retsema, J.A., Girard, A.E., Brennan, L.A., Cimochow-ski, C.R., Faiella, J.A. Lack of emergence of significant resistance in vitro and in vivo to the new azalide antibiotic azithromycin. European Journal of Clinical Microbiology and Infectious Diseases 1991; 10: 843 6. - PubMed
  31. Cox, U., Hoskins, J.D., Roy, A.F., Newman, S.S., Luther, D.G. Antimicrobial susceptibility of coagulase-positive staphylococci isolated from Louisiana dogs. American Journal of Veterinary Research 1984; 45: 2039 42. - PubMed
  32. Kruse, H., Hofshagen, M., Thoresen, S.I., Bredal, W.P., Vollset, I., Soli, N.E. The antimicrobial susceptibility of Staphylococcus species isolated from canine dermatitis. Veterinary Research Communications 1996; 20: 205 14. - PubMed
  33. Pedersen-Morner, A., Bergstrom, K., Greko, C., Franklin, A. Antibiotic sensitivity of Staphylococci isolated from cases of canine pyoderma. Compendium on Continuing Education for Practising Veterinarians 1998; 18: 48. - PubMed
  34. Pellerin, J.L., Bourdeau, P., Sebbag, H., Person, J.M. Epidemiosurveillance of antimicrobial compound resistance of Staphylococcus intermedius clinical isolates from canine pyodermas. Compendium of Immunolology, Microbiology and Infectious Diseases 1998; 21: 115 33. - PubMed
  35. Medleau, L., Long, R.E., Brown, J., Miller, W.H. Jr Frequency and antimicrobial susceptibility of Staphylo-coccus species isolated from canine pyodermas. American Journal of Veterinary Research 1986; 47: 229 31. - PubMed
  36. Phillips, W.E. & Williams, B.J. Antimicrobial susceptibility patterns of canine Staphylococcus intermedius isolates from veterinary clinical specimen. American Journal of Veterinary Research 1984; 45: 2376 9. - PubMed
  37. De Saxe, M. & Lloyd, D. Antibiotic resistance and other characters of Staphylococcus aureus isolates from dogs. Newsletter and Proceedings of the Association for Veterinary Clinical Pharmacology and Therapeutics 1982; 6: 50 4. - PubMed
  38. Woldehiwet, Z. & Jones, J.J. Species distribution of coagulase-positive staphylococci isolated from dogs. Veterinary Record 1990; 126: 485. - PubMed
  39. Noble, W.C. & Kent, L.E. Antibiotic resistance in Staphylococcus intermedius isolated from cases of pyoderma in the dog. Veterinary Dermatology 1992; 3: 71 4. - PubMed

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