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Chirgadze YN, Battaile KP, Likhachev IV, et al. Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. J Biomol Struct Dyn. 2021;1-10doi: 10.1080/07391102.2021.1994879.
Chirgadze, Y. N., Battaile, K. P., Likhachev, I. V., Balabaev, N. K., Gordon, R. D., Romanov, V., Lin, A., Karisch, R., Lam, R., Ruzanov, M., Brazhnikov, E. V., Pai, E. F., Neel, B. G., & Chirgadze, N. Y. (2021). Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. Journal of biomolecular structure & dynamics, 1-10. https://doi.org/10.1080/07391102.2021.1994879
Chirgadze, Yuri N, et al. "Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058." Journal of biomolecular structure & dynamics vol. (2021): 1-10. doi: https://doi.org/10.1080/07391102.2021.1994879
Chirgadze YN, Battaile KP, Likhachev IV, Balabaev NK, Gordon RD, Romanov V, Lin A, Karisch R, Lam R, Ruzanov M, Brazhnikov EV, Pai EF, Neel BG, Chirgadze NY. Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. J Biomol Struct Dyn. 2021 Oct 27;1-10. doi: 10.1080/07391102.2021.1994879. Epub 2021 Oct 27. PMID: 34705594.
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J Biomol Struct Dyn. 2021 Oct 27;1-10. doi: 10.1080/07391102.2021.1994879. Epub 2021 Oct 27.

Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058.

Journal of biomolecular structure & dynamics

Yuri N Chirgadze, Kevin P Battaile, Ilya V Likhachev, Nikolay K Balabaev, Roni D Gordon, Vladimir Romanov, Andres Lin, Robert Karisch, Robert Lam, Max Ruzanov, Evgeniy V Brazhnikov, Emil F Pai, Benjamin G Neel, Nickolay Y Chirgadze

Affiliations

  1. Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
  2. New York Structural Biology Center, New York, NY, USA.
  3. Institute of Mathematical Problems of Biology, Branch of Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
  4. Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.
  5. Molecular Structure and Design, Molecular Discovery Technologies, Bristol-Myers Squibb Research & Development, Princeton, NJ, USA.
  6. Department of Biochemistry and Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  7. Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, NY, USA.
  8. X-CHIP Technologies Inc., Toronto, ON, Canada.

PMID: 34705594 DOI: 10.1080/07391102.2021.1994879

Abstract

Protein tyrosine phosphatases constitute a family of cytosolic and receptor-like signal transducing enzymes that catalyze the hydrolysis of phospho-tyrosine residues of phosphorylated proteins. PTP1B, encoded by

Keywords: PTP1B; Protein tyrosine phosphatase; allosteric inhibitor; signal transfer

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