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Lucas S, Tencerova M, von der Weid B, et al. Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society. Front Endocrinol (Lausanne). 2021;12:744527doi: 10.3389/fendo.2021.744527.
Lucas, S., Tencerova, M., von der Weid, B., Andersen, T. L., Attané, C., Behler-Janbeck, F., Cawthorn, W. P., Ivaska, K. K., Naveiras, O., Podgorski, I., Reagan, M. R., & van der Eerden, B. C. J. (2021). Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society. Frontiers in endocrinology, 12744527. https://doi.org/10.3389/fendo.2021.744527
Lucas, Stephanie, et al. "Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society." Frontiers in endocrinology vol. 12 (2021): 744527. doi: https://doi.org/10.3389/fendo.2021.744527
Lucas S, Tencerova M, von der Weid B, Andersen TL, Attané C, Behler-Janbeck F, Cawthorn WP, Ivaska KK, Naveiras O, Podgorski I, Reagan MR, van der Eerden BCJ. Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society. Front Endocrinol (Lausanne). 2021 Sep 27;12:744527. doi: 10.3389/fendo.2021.744527. eCollection 2021. PMID: 34646237; PMCID: PMC8503265.
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Front Endocrinol (Lausanne). 2021 Sep 27;12:744527. doi: 10.3389/fendo.2021.744527. eCollection 2021.

Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society.

Frontiers in endocrinology

Stephanie Lucas, Michaela Tencerova, Benoit von der Weid, Thomas Levin Andersen, Camille Attané, Friederike Behler-Janbeck, William P Cawthorn, Kaisa K Ivaska, Olaia Naveiras, Izabela Podgorski, Michaela R Reagan, Bram C J van der Eerden

Affiliations

  1. Marrow Adiposity and Bone Lab-MABLab ULR4490, Univ. Littoral Côte d'Opale, Boulogne-sur-Mer, Univ. Lille, CHU Lille, Lille, France.
  2. Molecular Physiology of Bone, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
  3. School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  4. Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  5. Department of Biomedical Sciences, Faculty of Biology and Medicine, Université de Lausanne, Lausanne, Switzerland.
  6. Clinical Cell Biology, Department of Pathology, Odense University Hospital, Odense, Denmark.
  7. Clinical Cell Biology, Pathology Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  8. Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
  9. Department of Forensic Medicine, Aarhus University, Aarhus, Denmark.
  10. Institute of Pharmacology and Structural Biology, Université de Toulouse, CNRS UMR 5089, Toulouse, France.
  11. Equipe labellisée Ligue contre le cancer, Toulouse, France.
  12. Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  13. Department of Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  14. British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
  15. Institute of Biomedicine, University of Turku, Turku, Finland.
  16. Hematology Service, Departments of Oncology and Laboratory Medicine, Lausanne University Hospital (CHUV), Université de Lausanne, Lausanne, Switzerland.
  17. Department of Pharmacology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI, United States.
  18. Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, United States.
  19. Graduate School for Biomedical Science, Tufts University, Boston, MA, United States.
  20. Laboratory for Calcium and Bone Metabolism, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.

PMID: 34646237 PMCID: PMC8503265 DOI: 10.3389/fendo.2021.744527

Abstract

Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded the number of publications using different sources of bone marrow adipose tissue (BMAT). However, each source of BMAT has its limitations in the number of downstream analyses for which it can be used. Based on this increased scientific demand, the International Bone Marrow Adiposity Society (BMAS) established a Biobanking Working Group to identify the challenges of biobanking for human BMA-related samples and to develop guidelines to advance establishment of biobanks for BMA research. BMA is a young, growing field with increased interest among many diverse scientific communities. These bring new perspectives and important biological questions on how to improve and build an international community with biobank databases that can be used and shared all over the world. However, to create internationally accessible biobanks, several practical and legislative issues must be addressed to create a general ethical protocol used in all institutes, to allow for exchange of biological material internationally. In this position paper, the BMAS Biobanking Working Group describes similarities and differences of patient information (PIF) and consent forms from different institutes and addresses a possibility to create uniform documents for BMA biobanking purposes. Further, based on discussion among Working Group members, we report an overview of the current isolation protocols for human bone marrow adipocytes (BMAds) and bone marrow stromal cells (BMSCs, formerly mesenchymal), highlighting the specific points crucial for effective isolation. Although we remain far from a unified BMAd isolation protocol and PIF, we have summarized all of these important aspects, which are needed to build a BMA biobank. In conclusion, we believe that harmonizing isolation protocols and PIF globally will help to build international collaborations and improve the quality and interpretation of BMA research outcomes.

Copyright © 2021 Lucas, Tencerova, von der Weid, Andersen, Attané, Behler-Janbeck, Cawthorn, Ivaska, Naveiras, Podgorski, Reagan and van der Eerden.

Keywords: biobanking; bone marrow adipocytes; bone marrow adiposity; bone marrow stromal cells; cell isolation protocols; clinical studies; international research networks; patient information

Conflict of interest statement

BE is chair and coordinator of the BMAS Working Group on Biobanking. All authors are members of the BMAS Working Group on Biobanking. BE, WC and ON are members of the BMAS Executive Board. SL, MR and

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