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Macaluso F, Weber KM, Rubin LH, et al. Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection. J Clin Endocrinol Metab. 2021;doi: 10.1210/clinem/dgab759.
Macaluso, F., Weber, K. M., Rubin, L. H., Dellinger, E., Holman, S., Minkoff, H., Keating, S., Merlin, L. R., & Gustafson, D. R. (2021). Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection. The Journal of clinical endocrinology and metabolism, . https://doi.org/10.1210/clinem/dgab759
Macaluso, Francesca, et al. "Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection." The Journal of clinical endocrinology and metabolism vol. (2021). doi: https://doi.org/10.1210/clinem/dgab759
Macaluso F, Weber KM, Rubin LH, Dellinger E, Holman S, Minkoff H, Keating S, Merlin LR, Gustafson DR. Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection. J Clin Endocrinol Metab. 2021 Oct 22; doi: 10.1210/clinem/dgab759. Epub 2021 Oct 22. PMID: 34677589.
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J Clin Endocrinol Metab. 2021 Oct 22; doi: 10.1210/clinem/dgab759. Epub 2021 Oct 22.

Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection.

The Journal of clinical endocrinology and metabolism

Francesca Macaluso, Kathleen M Weber, Leah H Rubin, Elaine Dellinger, Susan Holman, Howard Minkoff, Sheila Keating, Lisa R Merlin, Deborah R Gustafson

Affiliations

  1. College of Medicine, State University of New York Health Sciences University, Brooklyn, NY.
  2. Cook County Health/Hektoen Institute of Medicine, Chicago IL.
  3. Department of Neurology, Psychiatry, and Epidemiology, Johns Hopkins University, Baltimore, MD.
  4. Department of Medicine/STAR Program, State University of New York Health Sciences University, Brooklyn, NY.
  5. Department of Obstetrics and Gynecology, State University of New York Health Sciences University, Brooklyn, NY.
  6. Maimonides Hospital, Brooklyn, NY.
  7. GigaGen Medical Laboratory, San Francisco, CA.
  8. Department of Neurology, New York City Health and Hospitals/Kings County, Brooklyn, NY.
  9. Department of Neurology, State University of New York Health Sciences University, Brooklyn, NY.

PMID: 34677589 DOI: 10.1210/clinem/dgab759

Abstract

OBJECTIVE: To determine whether body mass index (BMI) and leptin were longitudinally associated over 10 years with neuropsychological performance (NP) among middle-aged women with HIV (WWH) versus without HIV.

METHODS: Women's Interagency HIV Study (WIHS) participants (301 WWH, 113 women without HIV from Brooklyn, New York City and Chicago had baseline and 10-year BMI (kg/m2) and fasting plasma leptin levels using commercial ELISA (ng/mL); and demographically-adjusted NP T-scores (attention/working memory, executive function (EF), processing speed, memory, learning, verbal fluency, motor function, global) at 10-year follow-up. Multivariable linear regression analyses, stratified by HIV-serostatus, examined associations between BMI, leptin, and NP.

RESULTS: Over 10 years, women (baseline age 39.8+/-9.2 years, 73% Black, 73% WWH) transitioned from average overweight (29.1+/-7.9 kg/m 2) to obese (30.5+/-7.9 kg/m 2) BMI. Leptin increased 11.4+/-26.4 ng/mL (p<0.0001). Higher baseline BMI and leptin predicted poorer 10-year EF among all women (BMI B=-6.97, 95%CI(-11.5, -2.45) p=0.003; leptin B=-1.90, 95%CI(-3.03, -0.76), p=0.001); higher baseline BMI predicted better memory performance (B=6.35, 95%CI(1.96, 10.7), p=0.005). Greater 10-year leptin increase predicted poorer EF (p=0.004), speed (p=0.029), verbal (p=0.021) and global (p=0.005) performance among all women, and WWH. Greater 10-year BMI increase predicted slower processing speed (p=0.043) among all women; and among WWH, poorer EF (p=0.012) and global (p=0.035) performance.

CONCLUSIONS: In middle-aged WIHS participants, 10-year increases in BMI and leptin were associated with poorer performance across multiple NP domains among all and WWH. Trajectories of adiposity measures over time may provide insight into the role of adipose tissue in brain health with aging.

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

Keywords: Body Mass Index; Cognition; HIV; Leptin; Obesity; Overweight; Women

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