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Ouchani M, Bachir H, Hamaz S, et al. Retroperitoneal Fibrosis: Beware of Lymphoma. Cureus. 2021;13(8):e17587doi: 10.7759/cureus.17587.
Ouchani, M., Bachir, H., Hamaz, S., Alaoui, H., & Serraj, K. (2021). Retroperitoneal Fibrosis: Beware of Lymphoma. Cureus, 13(8), e17587. https://doi.org/10.7759/cureus.17587
Ouchani, Mohamed, et al. "Retroperitoneal Fibrosis: Beware of Lymphoma." Cureus vol. 13,8 (2021): e17587. doi: https://doi.org/10.7759/cureus.17587
Ouchani M, Bachir H, Hamaz S, Alaoui H, Serraj K. Retroperitoneal Fibrosis: Beware of Lymphoma. Cureus. 2021 Aug 31;13(8):e17587. doi: 10.7759/cureus.17587. eCollection 2021 Aug. PMID: 34646640; PMCID: PMC8483394.
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Cureus. 2021 Aug 31;13(8):e17587. doi: 10.7759/cureus.17587. eCollection 2021 Aug.

Retroperitoneal Fibrosis: Beware of Lymphoma.

Cureus

Mohamed Ouchani, Houda Bachir, Siham Hamaz, Habiba Alaoui, Khalid Serraj

Affiliations

  1. Internal Medicine, Immunohematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
  2. Infectious Disease, Immunohematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.

PMID: 34646640 PMCID: PMC8483394 DOI: 10.7759/cureus.17587

Abstract

Retroperitoneal fibrosis is a rare disease manifesting as chronic soft tissue fibrosis in the retroperitoneum, with potential anatomic and/or functional compromise of adjacent organs. It can be primary (idiopathic) or secondary to other conditions such as cancers, radiotherapy, surgery, traumatisms, infections, autoimmune disorders, or drugs. We report herein a 54-year-old patient with symptomatic retroperitoneal fibrosis leading to bilateral hydronephrosis and renal failure, in whom, after a complex diagnostic workup and protracted clinical course, a follicular lymphoma in the retroperitoneal was identified. The patient was treated with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy protocol, with a resolution of hydronephrosis and lower back pain. We include a thorough literature review on etiopathogenesis, diagnosis, therapy, and prognosis of retroperitoneal fibrosis. A meticulous search for malignancy is necessary for this rare condition that, if positive, may have significant therapeutic and prognostic implications.

Copyright © 2021, Ouchani et al.

Keywords: biopsy of rpf; chemotherapy; corticosteroid therapy; follicular lymphoma; r-chop; retroperitoneal fibrosis

Conflict of interest statement

The authors have declared that no competing interests exist.

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