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Mojzesz M, Widziolek M, Adamek M, et al. Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior. Front Immunol. 2021;12:760882doi: 10.3389/fimmu.2021.760882.
Mojzesz, M., Widziolek, M., Adamek, M., Orzechowska, U., Podlasz, P., Prajsnar, T. K., Pooranachandran, N., Pecio, A., Michalik, A., Surachetpong, W., Chadzinska, M., & Rakus, K. (2021). Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior. Frontiers in immunology, 12760882. https://doi.org/10.3389/fimmu.2021.760882
Mojzesz, Miriam, et al. "Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior." Frontiers in immunology vol. 12 (2021): 760882. doi: https://doi.org/10.3389/fimmu.2021.760882
Mojzesz M, Widziolek M, Adamek M, Orzechowska U, Podlasz P, Prajsnar TK, Pooranachandran N, Pecio A, Michalik A, Surachetpong W, Chadzinska M, Rakus K. Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior. Front Immunol. 2021 Oct 11;12:760882. doi: 10.3389/fimmu.2021.760882. eCollection 2021. PMID: 34707620; PMCID: PMC8544261.
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Front Immunol. 2021 Oct 11;12:760882. doi: 10.3389/fimmu.2021.760882. eCollection 2021.

Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior.

Frontiers in immunology

Miriam Mojzesz, Magdalena Widziolek, Mikolaj Adamek, Urszula Orzechowska, Piotr Podlasz, Tomasz K Prajsnar, Niedharsan Pooranachandran, Anna Pecio, Anna Michalik, Win Surachetpong, Magdalena Chadzinska, Krzysztof Rakus

Affiliations

  1. Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
  2. Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany.
  3. Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland.
  4. Department of Comparative Anatomy, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
  5. Department of Invertebrate Development and Morphology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
  6. Department of Veterinary Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.

PMID: 34707620 PMCID: PMC8544261 DOI: 10.3389/fimmu.2021.760882

Abstract

In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited. To further investigate this subject, we used the model of tilapia lake virus (TiLV) infection of zebrafish (

Copyright © 2021 Mojzesz, Widziolek, Adamek, Orzechowska, Podlasz, Prajsnar, Pooranachandran, Pecio, Michalik, Surachetpong, Chadzinska and Rakus.

Keywords: TiLV; anti-viral response; interferons; microglia; neuroinflammation; sickness behavior; tilapia lake virus; zebrafish

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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