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Porwal A, Yadav YC, Pathak K, et al. An Update on Assessment, Therapeutic Management, and Patents on Insomnia. Biomed Res Int. 2021;2021:6068952doi: 10.1155/2021/6068952.
Porwal, A., Yadav, Y. C., Pathak, K., & Yadav, R. (2021). An Update on Assessment, Therapeutic Management, and Patents on Insomnia. BioMed research international, 20216068952. https://doi.org/10.1155/2021/6068952
Porwal, Amit, et al. "An Update on Assessment, Therapeutic Management, and Patents on Insomnia." BioMed research international vol. 2021 (2021): 6068952. doi: https://doi.org/10.1155/2021/6068952
Porwal A, Yadav YC, Pathak K, Yadav R. An Update on Assessment, Therapeutic Management, and Patents on Insomnia. Biomed Res Int. 2021 Oct 18;2021:6068952. doi: 10.1155/2021/6068952. eCollection 2021. PMID: 34708126; PMCID: PMC8545506.
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Biomed Res Int. 2021 Oct 18;2021:6068952. doi: 10.1155/2021/6068952. eCollection 2021.

An Update on Assessment, Therapeutic Management, and Patents on Insomnia.

BioMed research international

Amit Porwal, Yogesh Chand Yadav, Kamla Pathak, Ramakant Yadav

Affiliations

  1. Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, 206130 Uttar Pradesh, India.
  2. Faculty of Medical Sciences, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, 206130 Uttar Pradesh, India.

PMID: 34708126 PMCID: PMC8545506 DOI: 10.1155/2021/6068952

Abstract

Insomnia is an ordinary situation related to noticeable disability in function and quality of life, mental and actual sickness, and mishappenings. It represents more than 5.5 million appointments to family doctors every year. Nonetheless, the ratio of insomniacs who are treated keeps on being low, demonstrating the requirement for proceeding with advancement and dispersal of effective treatments. Accordingly, it becomes significant to provide a compelling treatment for clinical practice. It indicates a need for the determination of various critical viewpoints for the evaluation of insomnia along with various accessible alternatives for treatment. These alternatives incorporate both nonpharmacological therapy, specifically cognitive behavioural therapy for insomnia, and a number of pharmacological treatments like orexin antagonists, "z-drugs," benzodiazepines, selective histamine H1 antagonists, nonselective antihistamines, melatonin receptor agonists, antipsychotics, antidepressants, and anticonvulsants. Besides in individuals whose insomnia is due to restless leg syndrome, depression/mood disorder, or/and circadian disturbance, there is insignificant proof favouring the effectiveness of different prescriptions for the treatment of insomnia though they are widely used. Other pharmacological agents producing sedation should be prescribed with care for insomnia therapy because of greater risk of next-day sleepiness along with known adverse effects and toxicities. This review is also aimed at providing an update on various patents on dosage forms containing drugs for insomnia therapy.

Copyright © 2021 Amit Porwal et al.

Conflict of interest statement

The authors report no conflicts of interest.

References

  1. Sleep Med. 2018 Feb;42:90-96 - PubMed
  2. Can J Psychiatry. 2011 Sep;56(9):540-8 - PubMed
  3. Sleep. 1983;6(3):179-85 - PubMed
  4. Int J Neuropsychopharmacol. 2013 May;16(4):925-36 - PubMed
  5. Anaesthesia. 2002 May;57(5):451-62 - PubMed
  6. CMAJ. 2000 Jan 25;162(2):225-33 - PubMed
  7. Electroencephalogr Clin Neurophysiol. 1978 Nov;45(5):621-7 - PubMed
  8. Am J Med. 2015 Mar;128(3):268-75.e2 - PubMed
  9. Sleep Med Rev. 2008 Jun;12(3):211-28 - PubMed
  10. Trends Pharmacol Sci. 2007 Feb;28(2):75-82 - PubMed
  11. Sleep Med Clin. 2017 Sep;12(3):383-393 - PubMed
  12. J Med Chem. 2013 Sep 12;56(17):6901-16 - PubMed
  13. Sleep. 1979 Autumn;2(1):1-154 - PubMed
  14. Lancet Neurol. 2014 May;13(5):461-71 - PubMed
  15. Planta Med. 1994 Jun;60(3):278-9 - PubMed
  16. Sleep Med Rev. 2002 Apr;6(2):97-111 - PubMed
  17. Sleep Med Rev. 2009 Jun;13(3):205-14 - PubMed
  18. Sleep. 2009 Apr;32(4):491-7 - PubMed
  19. Sleep Med Rev. 2001 Feb;5(1):47-61 - PubMed
  20. Biol Psychiatry. 1996 Mar 15;39(6):411-8 - PubMed
  21. Sleep Med Rev. 2007 Apr;11(2):135-42 - PubMed
  22. Sleep. 2012 Jun 01;35(6):825-34 - PubMed
  23. Sleep Med Rev. 2013 Aug;17(4):263-72 - PubMed
  24. Subst Abus. 2003 Jun;24(2):129-32 - PubMed
  25. Neurogenetics. 2012 Nov;13(4):287-326 - PubMed
  26. Sleep. 2010 Mar;33(3):343-7 - PubMed
  27. Nat Sci Sleep. 2010 May 10;2:79-84 - PubMed
  28. Sleep Med. 2009 Oct;10(9):952-60 - PubMed
  29. Am Fam Physician. 2017 Jul 1;96(1):29-35 - PubMed
  30. J Abnorm Psychol. 2005 Feb;114(1):111-8 - PubMed
  31. Alcohol Clin Exp Res. 2013 Apr;37(4):539-49 - PubMed
  32. Sleep Med Rev. 2015 Feb;19:6-16 - PubMed
  33. Transl Psychiatry. 2019 Oct 2;9(1):240 - PubMed
  34. Sleep Med. 2007 Dec;8 Suppl 4:S9-14 - PubMed
  35. J Clin Sleep Med. 2018 Aug 15;14(8):1399-1408 - PubMed
  36. JAMA Intern Med. 2015 Sep;175(9):1472-3 - PubMed
  37. Med Clin North Am. 1985 Nov;69(6):1153-67 - PubMed
  38. Br J Pharmacol. 2004 Jan;141(2):340-6 - PubMed
  39. Psychiatry Res. 2011 May 30;187(3):397-400 - PubMed
  40. Drug Metab Dispos. 2011 Feb;39(2):215-27 - PubMed
  41. J Psychopharmacol. 2019 Feb;33(2):202-209 - PubMed
  42. J Psychosom Res. 1999 Feb;46(2):103-16 - PubMed
  43. Alcohol Clin Exp Res. 2008 Aug;32(8):1429-38 - PubMed
  44. Curr Med Res Opin. 2016 Oct;32(10):1611-1622 - PubMed
  45. Neuropsychiatr Dis Treat. 2017 Apr 26;13:1193-1200 - PubMed
  46. Br J Gen Pract. 2012 Feb;62(595):e99-103 - PubMed
  47. Sleep. 2005 Nov;28(11):1465-71 - PubMed
  48. Clin Psychol Rev. 2016 Feb;43:90-102 - PubMed
  49. Hum Toxicol. 1987 Sep;6(5):355-9 - PubMed
  50. Expert Rev Respir Med. 2014 Feb;8(1):79-88 - PubMed
  51. Sleep Med. 2007 Dec;8 Suppl 4:S3-8 - PubMed
  52. Aust Fam Physician. 2010 Jun;39(6):433-7 - PubMed
  53. Sleep. 1995 Jul;18(6):425-32 - PubMed
  54. Sleep. 2011 Jul 01;34(7):859-67 - PubMed
  55. J Abnorm Child Psychol. 2005 Apr;33(2):157-63 - PubMed
  56. Psychiatry Res. 1999 Jun 30;86(3):267-70 - PubMed
  57. Sleep Med Rev. 2000 Aug;4(4):387-402 - PubMed
  58. Neurology. 2012 Dec 4;79(23):2265-74 - PubMed
  59. Med Hypotheses. 1999 Mar;52(3):269-70 - PubMed
  60. Sleep. 2006 Nov;29(11):1398-414 - PubMed
  61. Biol Psychiatry. 2006 Jun 1;59(11):1052-60 - PubMed
  62. J Am Geriatr Soc. 2012 Apr;60(4):616-31 - PubMed
  63. Sleep. 2004 Sep 15;27(6):1163-9 - PubMed
  64. Sleep. 2008 Apr;31(4):473-80 - PubMed
  65. J Psychosom Res. 2000 Jun;48(6):555-60 - PubMed
  66. J Am Geriatr Soc. 2014 Feb;62(2):299-305 - PubMed
  67. J Clin Sleep Med. 2007 Aug 15;3(5):473-8 - PubMed
  68. Neuropharmacology. 2012 Feb;62(2):978-87 - PubMed
  69. J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1293-7 - PubMed
  70. Arch Intern Med. 2005 Jan 10;165(1):35-41 - PubMed
  71. Annu Rev Psychol. 2002;53:215-43 - PubMed
  72. Sleep Med Rev. 2015 Oct;23:54-67 - PubMed
  73. Am J Med. 2006 Dec;119(12):1005-12 - PubMed
  74. Br J Clin Pharmacol. 2009 Mar;67(3):333-40 - PubMed
  75. Biol Psychiatry. 2016 Jan 15;79(2):136-48 - PubMed
  76. J Androl. 2004 Mar-Apr;25(2):185-6; author reply 186-7 - PubMed
  77. Am J Med Genet B Neuropsychiatr Genet. 2003 Aug 15;121B(1):35-8 - PubMed
  78. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9 - PubMed
  79. J Am Geriatr Soc. 2009 May;57(5):761-89 - PubMed
  80. Adv Ther. 2010 Nov;27(11):796-813 - PubMed
  81. Sleep Med. 2006 Aug;7(5):397-406 - PubMed
  82. PLoS One. 2011 Apr 06;6(4):e18455 - PubMed
  83. Biol Psychiatry. 2006 Dec 15;60(12):1364-71 - PubMed
  84. J Psychiatr Res. 2003 Jan-Feb;37(1):9-15 - PubMed
  85. Ann Intern Med. 2016 Jul 19;165(2):125-33 - PubMed
  86. BMJ. 2012 Dec 17;345:e8343 - PubMed
  87. JAMA Intern Med. 2015 Sep;175(9):1461-72 - PubMed
  88. Anesth Analg. 2007 Dec;105(6):1805-15 - PubMed
  89. Obstet Gynecol. 2006 Dec;108(6):1402-10 - PubMed
  90. Sleep. 2014 Aug 01;37(8):1295-304 - PubMed
  91. Curr Opin Neurobiol. 2013 Oct;23(5):819-23 - PubMed
  92. Lancet. 2004 Nov 27-Dec 3;364(9449):1959-73 - PubMed
  93. Int Clin Psychopharmacol. 1998 Jul;13(4):157-67 - PubMed
  94. J Clin Sleep Med. 2008 Oct 15;4(5):487-504 - PubMed
  95. World Psychiatry. 2019 Oct;18(3):337-352 - PubMed
  96. Sleep. 2005 Sep;28(9):1049-57 - PubMed
  97. Sleep Med Rev. 2007 Feb;11(1):71-9 - PubMed
  98. Sleep. 2014 Aug 01;37(8):1283-93 - PubMed
  99. Sleep. 2007 Feb;30(2):213-8 - PubMed
  100. Ann Intern Med. 2014 Oct 7;161(7):ITC1-15; quiz ITC16 - PubMed
  101. J Psychosom Res. 2015 Jan;78(1):45-51 - PubMed
  102. Curr Opin Anaesthesiol. 2007 Oct;20(5):456-72 - PubMed
  103. Chest. 2014 Nov;146(5):1387-1394 - PubMed
  104. J Sleep Res. 2017 Dec;26(6):675-700 - PubMed
  105. Am J Geriatr Pharmacother. 2005 Dec;3(4):274-87 - PubMed
  106. J Clin Neurophysiol. 2001 Mar;18(2):128-47 - PubMed
  107. J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S38-42 - PubMed
  108. Nat Clin Pract Neurol. 2008 Aug;4(8):436-47 - PubMed
  109. Nat Sci Sleep. 2010 Apr 1;2:47-61 - PubMed
  110. Ann Neurol. 2020 Mar;87(3):347-356 - PubMed
  111. Sleep Med. 2010 Jan;11(1):69-74 - PubMed
  112. Travel Med Infect Dis. 2009 Mar;7(2):69-81 - PubMed
  113. P T. 2015 Nov;40(11):759-71 - PubMed
  114. Expert Opin Pharmacother. 2008 Feb;9(3):351-62 - PubMed
  115. Am J Psychiatry. 2004 Nov;161(11):2126-8 - PubMed
  116. Sleep. 2008 Apr;31(4):489-95 - PubMed
  117. Sleep Med Clin. 2016 Dec;11(4):531-541 - PubMed
  118. Sleep Med Rev. 2014 Oct;18(5):415-24 - PubMed
  119. J Affect Disord. 2003 Sep;76(1-3):255-9 - PubMed
  120. Neuropsychopharmacology. 2012 May;37(6):1548-57 - PubMed
  121. Sleep. 2012 Apr 01;35(4):571-7 - PubMed
  122. Sleep. 1991 Dec;14(6):540-5 - PubMed
  123. Chest. 2009 Feb;135(2):563-572 - PubMed
  124. Ann Thorac Med. 2016 Jul-Sep;11(3):202-10 - PubMed
  125. Chest. 2006 Jan;129(1):76-80 - PubMed
  126. J Clin Sleep Med. 2005 Oct 15;1(4):412-21 - PubMed
  127. J Psychosom Res. 2003 Sep;55(3):263-7 - PubMed
  128. Sleep Med Rev. 2010 Feb;14(1):9-15 - PubMed
  129. J Affect Disord. 2011 Dec;135(1-3):10-9 - PubMed
  130. Sleep. 2007 Mar;30(3):274-80 - PubMed
  131. Psychiatr Genet. 2012 Apr;22(2):82-7 - PubMed
  132. Ann Intern Med. 2015 Aug 4;163(3):191-204 - PubMed
  133. J Psychopharmacol. 2018 Jun;32(6):668-677 - PubMed
  134. J Clin Sleep Med. 2017 Feb 15;13(2):307-349 - PubMed
  135. Psychiatr Clin North Am. 2006 Dec;29(4):871-93; abstract vii-viii - PubMed
  136. Br J Pharmacol. 2001 Mar;132(6):1179-82 - PubMed
  137. Expert Opin Drug Discov. 2017 Jul;12(7):643-657 - PubMed
  138. Adv Pharmacol Sci. 2012;2012:416864 - PubMed
  139. Alcohol. 2015 Jun;49(4):299-310 - PubMed
  140. Biol Psychiatry. 2011 Mar 15;69(6):592-600 - PubMed
  141. Sleep Med Rev. 2010 Feb;14(1):19-31 - PubMed
  142. J Clin Psychiatry. 2012 Sep;73(9):e1160-7 - PubMed
  143. Eur J Pain. 2012 Apr;16(4):522-33 - PubMed
  144. J Clin Psychiatry. 2005;66 Suppl 5:11-6 - PubMed
  145. Sleep Med Rev. 2009 Aug;13(4):265-74 - PubMed
  146. Sleep Med Rev. 2018 Apr;38:3-16 - PubMed
  147. PLoS One. 2016 Feb 11;11(2):e0149139 - PubMed
  148. Altern Med Rev. 2000 Jun;5(3):249-59 - PubMed
  149. Arch Intern Med. 2006 Sep 18;166(16):1775-82 - PubMed
  150. Sleep Med Rev. 2008 Apr;12(2):153-62 - PubMed
  151. Sleep. 2012 Jun 01;35(6):807-14 - PubMed
  152. Pharm Pat Anal. 2014;3(6):625-38 - PubMed

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