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Pham T, Plata PL, Zhang P, et al. Knowledge-Based Design of 5-Fluororacil Prodrug Liposomal Formulation: Molecular Packing and Interaction Revealed by Interfacial Isotherms and X-ray Scattering Techniques. Mol Pharm. 2021;18(12):4331-4340doi: 10.1021/acs.molpharmaceut.1c00494.
Pham, T., Plata, P. L., Zhang, P., Vellara, A., Bu, W., Lin, B., Cheng, G., & Liu, Y. (2021). Knowledge-Based Design of 5-Fluororacil Prodrug Liposomal Formulation: Molecular Packing and Interaction Revealed by Interfacial Isotherms and X-ray Scattering Techniques. Molecular pharmaceutics, 18(12), 4331-4340. https://doi.org/10.1021/acs.molpharmaceut.1c00494
Pham, Tiep, et al. "Knowledge-Based Design of 5-Fluororacil Prodrug Liposomal Formulation: Molecular Packing and Interaction Revealed by Interfacial Isotherms and X-ray Scattering Techniques." Molecular pharmaceutics vol. 18,12 (2021): 4331-4340. doi: https://doi.org/10.1021/acs.molpharmaceut.1c00494
Pham T, Plata PL, Zhang P, Vellara A, Bu W, Lin B, Cheng G, Liu Y. Knowledge-Based Design of 5-Fluororacil Prodrug Liposomal Formulation: Molecular Packing and Interaction Revealed by Interfacial Isotherms and X-ray Scattering Techniques. Mol Pharm. 2021 Dec 06;18(12):4331-4340. doi: 10.1021/acs.molpharmaceut.1c00494. Epub 2021 Nov 05. PMID: 34739257.
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Mol Pharm. 2021 Dec 06;18(12):4331-4340. doi: 10.1021/acs.molpharmaceut.1c00494. Epub 2021 Nov 05.

Knowledge-Based Design of 5-Fluororacil Prodrug Liposomal Formulation: Molecular Packing and Interaction Revealed by Interfacial Isotherms and X-ray Scattering Techniques.

Molecular pharmaceutics

Tiep Pham, Paola Leon Plata, Pin Zhang, Anand Vellara, Wei Bu, Binhua Lin, Gang Cheng, Ying Liu

Affiliations

  1. Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois 60608 United States.
  2. NSF's ChemMatCARS and Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
  3. Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
  4. Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, United States.

PMID: 34739257 DOI: 10.1021/acs.molpharmaceut.1c00494

Abstract

Prodrugs and nanoformulations are two effective strategies for sustained drug release and targeting drug delivery. In this study, we combined the two strategies to judiciously design the liposome formulation incorporating an amphiphilic prodrug of 5-fouroracil (5-FU), named 5-FCPal, for sustained drug release and enhanced bioavailability. 5-FCPal is an analogue of capecitabine (N

Keywords: X-ray reflectivity; amphiphilic prodrug; grazing incidence diffraction; lipids; liposomes; molecular packing and interaction

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