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Su G, Qu Y, Li G, et al. Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1. Bioengineered. 2021;12(2):11858-11871doi: 10.1080/21655979.2021.1999551.
Su, G., Qu, Y., Li, G., & Deng, M. (2021). Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1. Bioengineered, 12(2), 11858-11871. https://doi.org/10.1080/21655979.2021.1999551
Su, Guoning, et al. "Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1." Bioengineered vol. 12,2 (2021): 11858-11871. doi: https://doi.org/10.1080/21655979.2021.1999551
Su G, Qu Y, Li G, Deng M. Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1. Bioengineered. 2021 Dec;12(2):11858-11871. doi: 10.1080/21655979.2021.1999551. PMID: 34709114.
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Bioengineered. 2021 Dec;12(2):11858-11871. doi: 10.1080/21655979.2021.1999551.

Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1.

Bioengineered

Guoning Su, Yan Qu, Gang Li, Min Deng

Affiliations

  1. Department of Anesthesia, Affiliated Hospital of Yunnan University, KunMing City, China.

PMID: 34709114 DOI: 10.1080/21655979.2021.1999551

Abstract

Sevoflurane (SEV) has been reported to be an effective neuroprotective agent for cerebral ischemia/reperfusion injury (CIRI). However, the precise molecular mechanisms of Sev preconditioning in CIRI remain largely unknown. Therefore, CIRI model was established via middle cerebral artery occlusion method. SEV was applied before modeling. after successful modeling, lentivirus was injected into the lateral ventricle of the brain. Neurological impairment score was performed in each group, and histopathologic condition, infarct volume, apoptosis, inflammation, oxidative stress, microRNA (miR)-30 c-5p and homeodomain-interacting protein kinase 1 (HIPK1) were detected. Mouse hippocampal neuronal cell line HT22 cells were pretreated with SEV, and the

Keywords: Cerebral ischemia-reperfusion injury; Homeodomain-interacting protein kinase 1; MicroRNA-30c-5p; Sevoflurane

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