J Am Podiatr Med Assoc. 2021 Oct 28; doi: 10.7547/20-143. Epub 2021 Oct 28.

Effect of a topical gel based on Adelmidrol + Trans-traumatic acid in the treatment of diabetic foot ulcers: an open-label study.

Journal of the American Podiatric Medical Association

Ilaria Teobaldi, Vincenzo Stoico, Fabrizia Perrone, Alessandro Mantovani, Patrizia Piccagli, Fiorenza Grandi, Barbara Baldo

PMID: 34709395 DOI: 10.7547/20-143

Abstract

BACKGROUND: Diabetic foot ulceration is a severe complication of diabetes characterized by chronic inflammation and impaired wound healing. This study aims to evaluate the effect of a medical device gel based on Adelmidrol + Trans traumatic acid in the healing process of diabetic foot ulcers.

METHODS: Thirty-seven diabetic patients with foot ulcers of mild/moderate grade were treated with the gel applied daily for 4 weeks on the affected area. The following parameters were evaluated at baseline and weekly: a) wound area, measured drawing a map of the ulcer then calculated with Photoshop6 tools, b) clinical appearance of the ulcer, assessed recording the presence/absence of dry/wet necrosis, infection, fibrin, neoepithelium, exudate, redness, granulation tissue.

RESULTS: Topical treatment led to progressive healing of diabetic foot ulcers with a significant reduction of the wound area and an improvement in the clinical appearance of the ulcers. No adverse events treatment-related were observed.

CONCLUSIONS: The results of this open-label study show the potential benefits of Adelmidrol + Trans traumatic acid topical administration to promote re-epithelialization of diabetic foot ulcers. Further studies need to confirm the observed results.

Keywords: Adelmidrol; Diabetic foot; Healing of chronic wounds; Topical treatment

Publication Types

• Journal Article