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Delmas MC, Bénézet L, Ribet C, et al. Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort. BMC Pulm Med. 2021;21(1):319doi: 10.1186/s12890-021-01688-z.
Delmas, M. C., Bénézet, L., Ribet, C., Iwatsubo, Y., Zins, M., Nadif, R., Roche, N., & Leynaert, B. (2021). Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort. BMC pulmonary medicine, 21(1), 319. https://doi.org/10.1186/s12890-021-01688-z
Delmas, Marie-Christine, et al. "Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort." BMC pulmonary medicine vol. 21,1 (2021): 319. doi: https://doi.org/10.1186/s12890-021-01688-z
Delmas MC, Bénézet L, Ribet C, Iwatsubo Y, Zins M, Nadif R, Roche N, Leynaert B. Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort. BMC Pulm Med. 2021 Oct 14;21(1):319. doi: 10.1186/s12890-021-01688-z. PMID: 34649556; PMCID: PMC8518215.
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BMC Pulm Med. 2021 Oct 14;21(1):319. doi: 10.1186/s12890-021-01688-z.

Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort.

BMC pulmonary medicine

Marie-Christine Delmas, Laetitia Bénézet, Céline Ribet, Yuriko Iwatsubo, Marie Zins, Rachel Nadif, Nicolas Roche, Bénédicte Leynaert

Affiliations

  1. Santé Publique France, French National Public Health Agency, 12 Rue du Val d'Osne, 94415, Saint-Maurice Cedex, France. [email protected].
  2. Santé Publique France, French National Public Health Agency, 12 Rue du Val d'Osne, 94415, Saint-Maurice Cedex, France.
  3. Inserm UMS 011, Population-Based Epidemiological Cohorts, Villejuif, France.
  4. Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, Université Paris-Saclay, UVSQ, Université Paris-Sud, Villejuif, France.
  5. APHP Centre, Hôpital et Institut Cochin, Service de Pneumologie, Université de Paris, Paris, France.

PMID: 34649556 PMCID: PMC8518215 DOI: 10.1186/s12890-021-01688-z

Abstract

BACKGROUND: The burden of undiagnosed obstructive lung disease (OLD) (mainly asthma and chronic obstructive pulmonary disease) is not fully established, and targets for corrective action are yet to be identified. We assessed the underdiagnosis of OLD and its determinants in France.

METHODS: CONSTANCES is a French population-based cohort of adults aged 18-69 years at inception. We analysed data collected at inclusion in 2013-2014. Undiagnosed OLD was defined as spirometry-confirmed airflow limitation (FEV

RESULTS: Spirometry results were available for 19,398 participants. The prevalence of airflow limitation was 4.6%. Overall, 64.4% of adults with airflow limitation did not report a previous diagnosis of OLD. Individuals with high cumulative tobacco consumption (≥ 10 pack-years) (aPR: 1.72 [1.28-2.32]), without respiratory symptoms (aPR: 1.51 [1.28-1.78]), and with preserved lung function (aPR: 1.21 [1.04-1.41] for a 10-point increase in FEV

CONCLUSION: Underdiagnosis of OLD is very common among French adults, even in patients with respiratory symptoms. Efforts should be made in France to raise awareness about OLD in the general population, improve the detection of respiratory symptoms, and increase the use of spirometry among primary care professionals.

© 2021. The Author(s).

Keywords: Asthma; COPD; France; Obstructive lung disease; Underdiagnosis

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