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Myers PH, Goulding DR, Wiltshire RA, et al. Serum Buprenorphine Concentrations and Behavioral Activity in Mice After a Single Subcutaneous Injection of Simbadol, Buprenorphine SR-LAB, or Standard Buprenorphine. J Am Assoc Lab Anim Sci. 2021;60(6):661-666doi: 10.30802/AALAS-JAALAS-21-000028.
Myers, P. H., Goulding, D. R., Wiltshire, R. A., McGee, C. A., Dickerson, A. B., Comins, M. M., Shi, M., Kissling, G. E., Lih, F. B., Deterding, L. J., Laber-Laird, K. E., & Blankenship-Paris, T. L. (2021). Serum Buprenorphine Concentrations and Behavioral Activity in Mice After a Single Subcutaneous Injection of Simbadol, Buprenorphine SR-LAB, or Standard Buprenorphine. Journal of the American Association for Laboratory Animal Science : JAALAS, 60(6), 661-666. https://doi.org/10.30802/AALAS-JAALAS-21-000028
Myers, Page H, et al. "Serum Buprenorphine Concentrations and Behavioral Activity in Mice After a Single Subcutaneous Injection of Simbadol, Buprenorphine SR-LAB, or Standard Buprenorphine." Journal of the American Association for Laboratory Animal Science : JAALAS vol. 60,6 (2021): 661-666. doi: https://doi.org/10.30802/AALAS-JAALAS-21-000028
Myers PH, Goulding DR, Wiltshire RA, McGee CA, Dickerson AB, Comins MM, Shi M, Kissling GE, Lih FB, Deterding LJ, Laber-Laird KE, Blankenship-Paris TL. Serum Buprenorphine Concentrations and Behavioral Activity in Mice After a Single Subcutaneous Injection of Simbadol, Buprenorphine SR-LAB, or Standard Buprenorphine. J Am Assoc Lab Anim Sci. 2021 Nov 01;60(6):661-666. doi: 10.30802/AALAS-JAALAS-21-000028. Epub 2021 Nov 05. PMID: 34740385; PMCID: PMC8628526.
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J Am Assoc Lab Anim Sci. 2021 Nov 01;60(6):661-666. doi: 10.30802/AALAS-JAALAS-21-000028. Epub 2021 Nov 05.

Serum Buprenorphine Concentrations and Behavioral Activity in Mice After a Single Subcutaneous Injection of Simbadol, Buprenorphine SR-LAB, or Standard Buprenorphine.

Journal of the American Association for Laboratory Animal Science : JAALAS

Page H Myers, David R Goulding, Rebecca A Wiltshire, Christopher A McGee, Angela B Dickerson, Molly M Comins, Min Shi, Grace E Kissling, Fred B Lih, Leesa J Deterding, Kathy E Laber-Laird, Terry L Blankenship-Paris

Affiliations

  1. Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, North Carolina.
  2. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, North Carolina.
  3. Mass Spectrometry Research and Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, North Carolina.

PMID: 34740385 PMCID: PMC8628526 DOI: 10.30802/AALAS-JAALAS-21-000028

Abstract

Buprenorphine, an analgesic commonly used in rodent surgery, requires repeated dosing every 4 to 6 h in order to provide adequate analgesia. However, redosing requires repeated handling, which may itself cause stress. Buprenorphine SR-LAB, which reportedly maintains serum levels of buprenorphine greater than 1 ng/mL for 48 to 72 h, is commercially available. However, the viscosity of the product and small dosing volumes make accurate dosing a challenge. Simbadol is a concentrated formulation of buprenorphine hydrochloride labeled for use in cats with recommended dosing frequency of every 24 h. We measured serum concentrations over time after a single injection of this product in C57BL/6NCrl mice and compared it to standard buprenorphine (Buprenex) and Buprenorphine SR-LAB. Male and female mice were injected subcutaneously with one of the 3 buprenorphine formulations at a dose of 1 mg/kg at time 0. Groups of mice (

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