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Delgado Caceres M, Angerpointner K, Galler M, et al. Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon. Cell Death Dis. 2021;12(11):1049doi: 10.1038/s41419-021-04298-z.
Delgado Caceres, M., Angerpointner, K., Galler, M., Lin, D., Michel, P. A., Brochhausen, C., Lu, X., Varadarajan, A. R., Warfsmann, J., Stange, R., Alt, V., Pfeifer, C. G., & Docheva, D. (2021). Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon. Cell death & disease, 12(11), 1049. https://doi.org/10.1038/s41419-021-04298-z
Delgado Caceres, Manuel, et al. "Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon." Cell death & disease vol. 12,11 (2021): 1049. doi: https://doi.org/10.1038/s41419-021-04298-z
Delgado Caceres M, Angerpointner K, Galler M, Lin D, Michel PA, Brochhausen C, Lu X, Varadarajan AR, Warfsmann J, Stange R, Alt V, Pfeifer CG, Docheva D. Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon. Cell Death Dis. 2021 Nov 05;12(11):1049. doi: 10.1038/s41419-021-04298-z. PMID: 34741033; PMCID: PMC8571417.
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Cell Death Dis. 2021 Nov 05;12(11):1049. doi: 10.1038/s41419-021-04298-z.

Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.

Cell death & disease

Manuel Delgado Caceres, Katharina Angerpointner, Michael Galler, Dasheng Lin, Philipp A Michel, Christoph Brochhausen, Xin Lu, Adithi R Varadarajan, Jens Warfsmann, Richard Stange, Volker Alt, Christian G Pfeifer, Denitsa Docheva

Affiliations

  1. Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
  2. Hand, Elbow and Plastic Surgery Department, Schön Klinik München Harlaching, Munich, Germany.
  3. Department of Trauma Surgery, Caritas Hospital St. Josef, Regensburg, Germany.
  4. Orthopaedic Center of People's Liberation Army, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, China.
  5. Department of Trauma-, Hand-, and Reconstructive Surgery, University Hospital Münster, Münster, Germany.
  6. Institute of Pathology, University of Regensburg, Regensburg, Germany.
  7. Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany.
  8. Department of Regenerative Musculoskeletal Medicine, Institute for Musculoskeletal Medicine, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany.
  9. Clinic and Policlinic for Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
  10. Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany. [email protected].
  11. Department of Musculoskeletal Tissue Regeneration, Orthopaedic Hospital König-Ludwig-Haus, University of Würzburg, Würzburg, Germany. [email protected].

PMID: 34741033 PMCID: PMC8571417 DOI: 10.1038/s41419-021-04298-z

Abstract

Heterotopic ossification (HO) represents a common problem after tendon injury with no effective treatment yet being developed. Tenomodulin (Tnmd), the best-known mature marker for tendon lineage cells, has important effects in tendon tissue aging and function. We have reported that loss of Tnmd leads to inferior early tendon repair characterized by fibrovascular scaring and therefore hypothesized that its lack will persistently cause deficient repair during later stages. Tnmd knockout (Tnmd

© 2021. The Author(s).

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