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Biomedicines. 2021 Oct 14;9(10). doi: 10.3390/biomedicines9101475.

Associations between SNPs in Intestinal Cholesterol Absorption and Endogenous Cholesterol Synthesis Genes with Cholesterol Metabolism.

Biomedicines

Maite M Schroor, Fatma B A Mokhtar, Jogchum Plat, Ronald P Mensink

Affiliations

  1. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.

PMID: 34680591 PMCID: PMC8533139 DOI: 10.3390/biomedicines9101475

Abstract

Single nucleotide polymorphisms (SNPs) have been associated with cholesterol metabolism and may partly explain large inter-individual variability in intestinal cholesterol absorption and endogenous cholesterol synthesis rates. This cross-sectional study therefore examined whether SNPs in genes encoding for proteins involved in intestinal cholesterol absorption (

Keywords: campesterol; cholesterol absorption; cholesterol biosynthesis; cholesterol metabolism; genetic variants; genetics; lathosterol; sitosterol; sterols

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