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Hajipour S, Farbood Y, Dianat M, et al. Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats. Iran J Basic Med Sci. 2021;24(7):881-891doi: 10.22038/ijbms.2021.52824.11913.
Hajipour, S., Farbood, Y., Dianat, M., Rashno, M., Khorsandi, L. S., & Sarkaki, A. (2021). Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats. Iranian journal of basic medical sciences, 24(7), 881-891. https://doi.org/10.22038/ijbms.2021.52824.11913
Hajipour, Somayeh, et al. "Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats." Iranian journal of basic medical sciences vol. 24,7 (2021): 881-891. doi: https://doi.org/10.22038/ijbms.2021.52824.11913
Hajipour S, Farbood Y, Dianat M, Rashno M, Khorsandi LS, Sarkaki A. Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats. Iran J Basic Med Sci. 2021 Jul;24(7):881-891. doi: 10.22038/ijbms.2021.52824.11913. PMID: 34712417; PMCID: PMC8528250.
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Iran J Basic Med Sci. 2021 Jul;24(7):881-891. doi: 10.22038/ijbms.2021.52824.11913.

Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats.

Iranian journal of basic medical sciences

Somayeh Hajipour, Yaghoob Farbood, Mahin Dianat, Mohammad Rashno, Laya Sadat Khorsandi, Alireza Sarkaki

Affiliations

  1. Persian Gulf Physiology Research Center. Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  2. Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  3. Department of Immunology, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of.
  4. Medical Sciences, Ahvaz, Iran.
  5. Department of Anatomical Sciences, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University.

PMID: 34712417 PMCID: PMC8528250 DOI: 10.22038/ijbms.2021.52824.11913

Abstract

OBJECTIVES: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that causes brain disturbances. Thymoquinone (TQ) has a wide spectrum of activities such as antioxidant, anti-inflammatory, and anticancer. This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy.

MATERIALS AND METHODS: Adult male Wistar rats were divided into six groups randomly: 1) Control; 2) HE, received TAA (200 mg/kg); 3-5) Treated groups (HE+TQ5, HE+TQ10, and HE+TQ20). TQ (5, 10, and 20 mg/kg) was injected intraperitoneally (IP) for 12 consecutive days from day 18 to 29. Subsequently, spatial memory performance was evaluated by the Morris water maze paradigm and hippocampal LTP was recorded from the dentate gyrus (DG) region. Activity levels of Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in the hippocampal tissue.

RESULTS: Data showed that the hippocampal content of MDA was increased while SOD activities were decreased in TAA-induced HE. TQ treatment significantly improved spatial memory and LTP. Moreover, TQ restored the levels of MDA and SOD activities in the hippocampal tissue in HE rats.

CONCLUSION: Our data confirm that TQ could attenuate cognitive impairment and improve LTP deficit by modulating the oxidative stress parameters in this model of HE, which leads to impairment of spatial cognition and LTP deficit. Thus, these results suggest that TQ may be a promising agent with positive therapeutic effects against liver failure and HE defects.

Keywords: Hepatic encephalopathy; LTP; Oxidative stress; Spatial cognition; Thioacetamide; Thymoquinone

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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