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Ordóñez-Gutiérrez L, Fábrias G, Casas J, et al. Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice. Int J Mol Sci. 2021;22(20)doi: 10.3390/ijms222010907.
Ordóñez-Gutiérrez, L., Fábrias, G., Casas, J., & Wandosell, F. (2021). Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice. International journal of molecular sciences, 22(20), . https://doi.org/10.3390/ijms222010907
Ordóñez-Gutiérrez, Lara, et al. "Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice." International journal of molecular sciences vol. 22,20 (2021). doi: https://doi.org/10.3390/ijms222010907
Ordóñez-Gutiérrez L, Fábrias G, Casas J, Wandosell F. Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice. Int J Mol Sci. 2021 Oct 09;22(20). doi: 10.3390/ijms222010907. PMID: 34681567; PMCID: PMC8535881.
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Int J Mol Sci. 2021 Oct 09;22(20). doi: 10.3390/ijms222010907.

Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice.

International journal of molecular sciences

Lara Ordóñez-Gutiérrez, Gemma Fábrias, Josefina Casas, Francisco Wandosell

Affiliations

  1. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28049 Madrid, Spain.
  2. Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), 28049 Madrid, Spain.
  3. Instituto de Química Avanzada de Cataluña (IQAC-CSIC), 080034 Barcelona, Spain.

PMID: 34681567 PMCID: PMC8535881 DOI: 10.3390/ijms222010907

Abstract

Senile plaque formation as a consequence of amyloid-β peptide (Aβ) aggregation constitutes one of the main hallmarks of Alzheimer's disease (AD). This pathology is characterized by synaptic alterations and cognitive impairment. In order to either prevent or revert it, different therapeutic approaches have been proposed, and some of them are focused on diet modification. Modification of the ω-6/ω-3 fatty acids (FA) ratio in diets has been proven to affect Aβ production and senile plaque formation in the hippocampus and cortex of female transgenic (TG) mice. In these diets, linoleic acid is the main contribution of ω-6 FA, whereas alpha-linoleic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) are the contributors of ω-3 FA. In the present work, we have explored the effect of ω-6/ω-3 ratio modifications in the diets of male double-transgenic APPswe/PS1ΔE9 (AD model) and wild-type mice (WT). Amyloid burden in the hippocampus increased in parallel with the increase in dietary ω-6/ω-3 ratio in TG male mice. In addition, there was a modification in the brain lipid profile proportional to the ω-6/ω-3 ratio of the diet. In particular, the higher the ω-6/ω-3 ratio, the lower the ceramides and higher the FAs, particularly docosatetraenoic acid. Modifications to the cortex lipid profile was mostly similar between TG and WT mice, except for gangliosides (higher levels in TG mice) and some ceramide species (lower levels in TG mice).

Keywords: Alzheimer; PUFA; amyloid; ceramides; neurodegeneration; ω-6/ω-3

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