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Carrasco A, Sjölander I, Van Acker A, et al. The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea. Front Immunol. 2021;12:674080doi: 10.3389/fimmu.2021.674080.
Carrasco, A., Sjölander, I., Van Acker, A., Dernstedt, A., Fehrm, J., Forsell, M., Friberg, D., Mjösberg, J., & Rao, A. (2021). The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea. Frontiers in immunology, 12674080. https://doi.org/10.3389/fimmu.2021.674080
Carrasco, Anna, et al. "The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea." Frontiers in immunology vol. 12 (2021): 674080. doi: https://doi.org/10.3389/fimmu.2021.674080
Carrasco A, Sjölander I, Van Acker A, Dernstedt A, Fehrm J, Forsell M, Friberg D, Mjösberg J, Rao A. The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea. Front Immunol. 2021 Oct 22;12:674080. doi: 10.3389/fimmu.2021.674080. eCollection 2021. PMID: 34745084; PMCID: PMC8570126.
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Front Immunol. 2021 Oct 22;12:674080. doi: 10.3389/fimmu.2021.674080. eCollection 2021.

The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea.

Frontiers in immunology

Anna Carrasco, Isabella Sjölander, Aline Van Acker, Andy Dernstedt, Johan Fehrm, Mattias Forsell, Danielle Friberg, Jenny Mjösberg, Anna Rao

Affiliations

  1. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  2. Department of Surgical Sciences, Otorhinolaryngology-Head and Neck Surgery, Uppsala University, Uppsala, Sweden.
  3. Department of Clinical Microbiology, Section of Infection and Immunology, Umeå University, Umeå, Sweden.
  4. Department of Clinical Sciences, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden.

PMID: 34745084 PMCID: PMC8570126 DOI: 10.3389/fimmu.2021.674080

Abstract

Tonsil hyperplasia is the most common cause of pediatric obstructive sleep apnea (OSA). Despite the growing knowledge in tissue immunology of tonsils, the immunopathology driving tonsil hyperplasia and OSA remains unknown. Here we used multi-parametric flow cytometry to analyze the composition and phenotype of tonsillar innate lymphoid cells (ILCs), T cells, and B cells from pediatric patients with OSA, who had previous polysomnography. Unbiased clustering analysis was used to delineate and compare lymphocyte heterogeneity between two patient groups: children with small tonsils and moderate OSA (n = 6) or large tonsils and very severe OSA (n = 13). We detected disturbed ILC and B cell proportions in patients with large tonsils, characterized by an increase in the frequency of naïve CD27

Copyright © 2021 Carrasco, Sjölander, Van Acker, Dernstedt, Fehrm, Forsell, Friberg, Mjösberg and Rao.

Keywords: B cells; Innate lymphoid cell (ILC); T cells; Tonsils; obstructive sleep apnea

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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