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Leone C, Di Lionardo A, Di Pietro G, et al. How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex. Clin Neurophysiol. 2021;132(12):2989-2995doi: 10.1016/j.clinph.2021.08.018.
Leone, C., Di Lionardo, A., Di Pietro, G., Di Stefano, G., Falco, P., Blockeel, A. J., Caspani, O., Garcia-Larrea, L., Mouraux, A., Phillips, K. G., Treede, R. D., & Truini, A. (2021). How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 132(12), 2989-2995. https://doi.org/10.1016/j.clinph.2021.08.018
Leone, C, et al. "How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex." Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology vol. 132,12 (2021): 2989-2995. doi: https://doi.org/10.1016/j.clinph.2021.08.018
Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A. How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex. Clin Neurophysiol. 2021 Dec;132(12):2989-2995. doi: 10.1016/j.clinph.2021.08.018. Epub 2021 Oct 05. PMID: 34715423.
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Clin Neurophysiol. 2021 Dec;132(12):2989-2995. doi: 10.1016/j.clinph.2021.08.018. Epub 2021 Oct 05.

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

C Leone, A Di Lionardo, G Di Pietro, G Di Stefano, P Falco, A J Blockeel, O Caspani, L Garcia-Larrea, A Mouraux, K G Phillips, R D Treede, A Truini

Affiliations

  1. Department of Human Neuroscience, Sapienza University, Rome, Italy.
  2. School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  3. Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.
  4. Lyon Neurosciences Center Research Unit Inserm U 1028, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France; Pain Center, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France.
  5. Université Catholique de Louvain, Institute of Neuroscience (IoNS), Faculty of Medicine, Bruxelles, Belgium.
  6. Lilly United Kingdom Erl Wood Manor Windlesham, Surrey, United Kingdom.
  7. Department of Human Neuroscience, Sapienza University, Rome, Italy. Electronic address: [email protected].

PMID: 34715423 DOI: 10.1016/j.clinph.2021.08.018

Abstract

OBJECTIVE: In this neurophysiological study in healthy humans, we assessed how central sensitization induced by either high-frequency stimulation (HFS) or topical capsaicin application modulates features of the RIII reflex response. The ability of these stimuli to engage the endogenous pain modulatory system was also tested.

METHODS: In 26 healthy participants we elicited an RIII reflex using suprathreshold stimulation of the sural nerve. Subsequently HFS or capsaicin were applied to the foot and the RIII reflex repeated after 15 minutes. Contact heating of the volar forearm served as the heterotopic test stimulus to probe activation of the endogenous pain modulatory system.

RESULTS: HFS significantly reduced the pain threshold by 29% and the RIII reflex threshold by 20%. Capsaicin significantly reduced the pain threshold by 17% and the RIII reflex threshold by 18%. Both HFS and capsaicin left RIII reflex size unaffected. Numerical Rating Scale (NRS) pain scores elicited by the heterotopic noxious heat stimulus were unaffected by capsaicin and slightly increased by HFS.

CONCLUSIONS: HFS and capsaicin similarly modulated the pain threshold and RIII reflex threshold, without a concomitant inhibitory effect of the endogenous pain modulatory system.

SIGNIFICANCE: Our neurophysiological study supports the use of the RIII reflex in investigating central sensitization in humans.

Copyright © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Keywords: Central sensitization; Neuropathic pain; Nociceptive reflex; Pain biomarker

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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