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Afami ME, El Karim I, About I, et al. Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp. Pharmaceutics. 2021;13(10)doi: 10.3390/pharmaceutics13101575.
Afami, M. E., El Karim, I., About, I., Krasnodembskaya, A. D., Laverty, G., & Lundy, F. T. (2021). Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp. Pharmaceutics, 13(10), . https://doi.org/10.3390/pharmaceutics13101575
Afami, Marina E, et al. "Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp." Pharmaceutics vol. 13,10 (2021). doi: https://doi.org/10.3390/pharmaceutics13101575
Afami ME, El Karim I, About I, Krasnodembskaya AD, Laverty G, Lundy FT. Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp. Pharmaceutics. 2021 Sep 28;13(10). doi: 10.3390/pharmaceutics13101575. PMID: 34683868; PMCID: PMC8539061.
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Pharmaceutics. 2021 Sep 28;13(10). doi: 10.3390/pharmaceutics13101575.

Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp.

Pharmaceutics

Marina E Afami, Ikhlas El Karim, Imad About, Anna D Krasnodembskaya, Garry Laverty, Fionnuala T Lundy

Affiliations

  1. Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  2. Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, 13385 Marseille, France.
  3. School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

PMID: 34683868 PMCID: PMC8539061 DOI: 10.3390/pharmaceutics13101575

Abstract

In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied extensively for their ability to inhibit micro-organisms relevant to tissue engineering sites such as dental root canals. In this work, we assess the biocompatibility of dental pulp stem/stromal cells with commercially available multicomponent peptide hydrogels. We also determine the effects of dental pulp stem/stromal cell (DPSC) culture in hydrogels on growth factor/cytokine expression. Furthermore, to investigate novel aspects of self-assembling peptide hydrogels, we determine their antimicrobial activity against the oral pathogens

Keywords: antibacterial; antimicrobial; biocompatibility; biofilm; cytokine; dental pulp; growth factor; hydrogel; oral pathogen; secretome

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