Display options
Cite
Lazarou I, Moraitou D, Papatheodorou M, et al. Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment. J Alzheimers Dis. 2021;84(3):1219-1232doi: 10.3233/JAD-210558.
Lazarou, I., Moraitou, D., Papatheodorou, M., Vavouras, I., Lokantidou, C., Agogiatou, C., Gialaoutzis, M., Nikolopoulos, S., Stavropoulos, T. G., Kompatsiaris, I., & Tsolaki, M. (2021). Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD, 84(3), 1219-1232. https://doi.org/10.3233/JAD-210558
Lazarou, Ioulietta, et al. "Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment." Journal of Alzheimer's disease : JAD vol. 84,3 (2021): 1219-1232. doi: https://doi.org/10.3233/JAD-210558
Lazarou I, Moraitou D, Papatheodorou M, Vavouras I, Lokantidou C, Agogiatou C, Gialaoutzis M, Nikolopoulos S, Stavropoulos TG, Kompatsiaris I, Tsolaki M. Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment. J Alzheimers Dis. 2021;84(3):1219-1232. doi: 10.3233/JAD-210558. PMID: 34657882.
Copy Download .nbib Format: NLM
Share it on

J Alzheimers Dis. 2021;84(3):1219-1232. doi: 10.3233/JAD-210558.

Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD

Ioulietta Lazarou, Despina Moraitou, Marianna Papatheodorou, Isaak Vavouras, Chrysanthi Lokantidou, Christina Agogiatou, Moses Gialaoutzis, Spiros Nikolopoulos, Thanos G Stavropoulos, Ioannis Kompatsiaris, Magda Tsolaki

Affiliations

  1. Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece.
  2. 1st Department of Neurology, G.H. "AHEPA", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  3. Laboratory of Psychology, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  4. Greek Association of Alzheimer's Disease and Related Disorders (GAADRD), Thessaloniki, Greece.

PMID: 34657882 DOI: 10.3233/JAD-210558

Abstract

BACKGROUND: The Memory Alteration Test (M@T) is a verbal episodic and semantic memory screening test able to detect subjective cognitive decline (SCD) and Mild Cognitive Impairment (MCI).

OBJECTIVE: To adapt M@T, creating a Greek version of the Memory Alteration Test (M@T-GR), and to validate M@T-GR compared to the Mini-Mental State Examination (MMSE), and Subjective Cognitive Decline- Questionnaire (SCD-Q) MyCog and TheirCog.

METHODS: 232 people over 55 years old participated in the study and they were classified as healthy controls (HC, n = 65), SCD (n = 78), or MCI (n = 89).

RESULTS: The ANCOVA showed that the M@T-GR's total score was significantly different in HC and SCD (I-J = 2.26, p = 0.032), HC and MCI (I-J = 6.16, p < 0.0001), and SCD compared to MCI (I-J = 3.90, p < 0.0001). In particular, a cut-off score of 46.50 points had an 81%sensitivity and 61%specificity for discriminating HC from SCD (AUC = 0.76, p < 0.0001), while a cut-off score of 45.50 had a sensitivity of 92%and a specificity of 73%for discriminating MCI (AUC = 0.88, p < 0.0001), and a cut-off score of 45.50 points had a sensitivity of 63%and a specificity of 73%for discriminating SCD from those with MCI (AUC = 0.69, p < 0.0021). Exploratory factor analysis indicated that there was one factor explaining 38.46%of the total variance. Internal consistency was adequate (α= 0.75), while convergent validity was found between M@T-GR and MMSE (r = 0.37, p < 0.0001) and SCD-Q TheirCog (r = -0.32, p < 0.0001).

CONCLUSION: The M@T-GR is a good to fair screening tool with adequate discriminant validity for administration in people with SCD and MCI in Greece.

Keywords: Alzheimer’s disease; diagnosis; memory alteration test; mild cognitive impairment; neuropsychological test; subjective cognitive decline

Publication Types