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Hsiao YT, Manikowski KJ, Snyder S, et al. NMUR1 in the NMU-Mediated Regulation of Bone Remodeling. Life (Basel). 2021;11(10)doi: 10.3390/life11101028.
Hsiao, Y. T., Manikowski, K. J., Snyder, S., Griffin, N., Orr, A. L., Hulsey, E. Q., Born-Evers, G., Zukosky, T., Squire, M. E., Hum, J. M., Metzger, C. E., Allen, M. R., & Lowery, J. W. (2021). NMUR1 in the NMU-Mediated Regulation of Bone Remodeling. Life (Basel, Switzerland), 11(10), . https://doi.org/10.3390/life11101028
Hsiao, Yu-Tin, et al. "NMUR1 in the NMU-Mediated Regulation of Bone Remodeling." Life (Basel, Switzerland) vol. 11,10 (2021). doi: https://doi.org/10.3390/life11101028
Hsiao YT, Manikowski KJ, Snyder S, Griffin N, Orr AL, Hulsey EQ, Born-Evers G, Zukosky T, Squire ME, Hum JM, Metzger CE, Allen MR, Lowery JW. NMUR1 in the NMU-Mediated Regulation of Bone Remodeling. Life (Basel). 2021 Sep 29;11(10). doi: 10.3390/life11101028. PMID: 34685399; PMCID: PMC8538501.
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Life (Basel). 2021 Sep 29;11(10). doi: 10.3390/life11101028.

NMUR1 in the NMU-Mediated Regulation of Bone Remodeling.

Life (Basel, Switzerland)

Yu-Tin Hsiao, Kelli J Manikowski, Samantha Snyder, Nicole Griffin, Ashley L Orr, Elizabeth Q Hulsey, Gabriella Born-Evers, Tara Zukosky, Maria E Squire, Julia M Hum, Corinne E Metzger, Matthew R Allen, Jonathan W Lowery

Affiliations

  1. Division of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46022, USA.
  2. Bone and Muscle Research Group, Marian University, Indianapolis, IN 46022, USA.
  3. Department of Biology, The University of Scranton, Scranton, PA 18503, USA.
  4. Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  5. Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

PMID: 34685399 PMCID: PMC8538501 DOI: 10.3390/life11101028

Abstract

Neuromedin-U (NMU) is an evolutionarily conserved peptide that regulates varying physiologic effects including blood pressure, stress and allergic responses, metabolic and feeding behavior, pain perception, and neuroendocrine functions. Recently, several lines of investigation implicate NMU in regulating bone remodeling. For instance, global loss of NMU expression in male and female mice leads to high bone mass due to elevated bone formation rate with no alteration in bone resorption rate or observable defect in skeletal patterning. Additionally, NMU treatment regulates the activity of osteoblasts in vitro. The downstream pathway utilized by NMU to carry out these effects is unknown as NMU signals via two G-protein-coupled receptors (GPCRs), NMU receptor 1 (NMUR1), and NMU receptor 2 (NMUR2), and both are expressed in the postnatal skeleton. Here, we sought to address this open question and build a better understanding of the downstream pathway utilized by NMU. Our approach involved the knockdown of

Keywords: NMU; NMUR1; NMUR2; Neuromedin-U; bone; osteoblast; osteoporosis

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