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Okamura S, Sairaku A, Tokuyama T, et al. Peripheral arterial tone during active standing. Pflugers Arch. 2021;473(12):1939-1946doi: 10.1007/s00424-021-02632-0.
Okamura, S., Sairaku, A., Tokuyama, T., Okubo, Y., Ikeuchi, Y., Miyauchi, S., Higashi, Y., & Nakano, Y. (2021). Peripheral arterial tone during active standing. Pflugers Archiv : European journal of physiology, 473(12), 1939-1946. https://doi.org/10.1007/s00424-021-02632-0
Okamura, Sho, et al. "Peripheral arterial tone during active standing." Pflugers Archiv : European journal of physiology vol. 473,12 (2021): 1939-1946. doi: https://doi.org/10.1007/s00424-021-02632-0
Okamura S, Sairaku A, Tokuyama T, Okubo Y, Ikeuchi Y, Miyauchi S, Higashi Y, Nakano Y. Peripheral arterial tone during active standing. Pflugers Arch. 2021 Dec;473(12):1939-1946. doi: 10.1007/s00424-021-02632-0. Epub 2021 Oct 31. PMID: 34718862.
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Pflugers Arch. 2021 Dec;473(12):1939-1946. doi: 10.1007/s00424-021-02632-0. Epub 2021 Oct 31.

Peripheral arterial tone during active standing.

Pflugers Archiv : European journal of physiology

Sho Okamura, Akinori Sairaku, Takehito Tokuyama, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi, Yukihito Higashi, Yukiko Nakano

Affiliations

  1. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  2. Department of Cardiology, Cardiovascular Center, Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, 722-8508, Japan. [email protected].
  3. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

PMID: 34718862 DOI: 10.1007/s00424-021-02632-0

Abstract

Active standing test is clinically used to detect inadequate sympathetic nervous system response to the orthostasis. Peripheral arterial tone (PAT) is a recently developed technology whereby sympathetic activity can be measured through monitoring the digit arterial pulsatile volume. We aimed to determine the response of PAT to the orthostasis. The PAT and short-time frequency domain heart rate variability (HRV) were simultaneously measured during a 5.5-min active standing test in volunteers. The endpoints were changes in the PAT and ratio of low frequency to high frequency (LH/HF) before and after the postural changes: sitting→standing→sitting again. The blood pressure (BP) was constant throughout the test while the heart rate increased during standing in 54 participants. The natural logarithm of the mean LF/HF increased in the standing position (sitting, standing, and sitting again, mean±standard deviation, 1.3±1.04, 1.73±1.15, and 1.51±0.94; p=0.006), and the natural logarithm of its peak value was the highest also while standing (2.58±1.19, 3.08±1.2, and 2.85±1.05; p=0.007). The mean PAT (487.5±277.7, 314.5±180.4, and 458.1±244.3; p <0.001) and its nadir value (341.8±204.8, 189.4±119.2, and 264.3±157.6; p <0.001) declined during standing, and reascended after sitting again. The percent change before and after the standing in mean PAT was not correlated with that of the mean LF/HF. In conclusion, the PAT changed independently of and inversely with the LF/HF during the orthostatic test while the BP remained constant, possibly reflecting peripheral vasocontraction needed for the BP homeostasis.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Autonomic function; Blood pressure homeostasis; Heart rate variability; Peripheral arterial tone

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